Cadherins play an important role in tissue homeostasis, as they are responsible for cell-cell
adhesion during embryogenesis, tissue morphogenesis, differentiation and carcinogenesis …

In this narrative review, a theoretical framework on the crosstalk between physical exercise
and blood-brain barrier (BBB) permeability is presented. We discuss the influence of …

MicroRNAs (miRNAs) are increasingly implicated in regulating the malignant progression of
cancer. Here we show that miR-9, which is upregulated in breast cancer cells, directly …

Contact inhibition of cell growth is essential for embryonic development and maintenance of
tissue architecture in adult organisms, and the growth of tumors is characterized by a loss of …

Cadherins are homophilic adhesion molecules with important functions in cell-cell adhesion,
tissue morphogenesis, and cancer. In epithelial cells, E-cadherin accumulates at areas of …

In addition to their adhesive functions, cell-adhesion molecules modulate signal-
transduction pathways by interacting with molecules such as receptor tyrosine kinases …

Aberrant Wnt signaling can drive cancer development. In many cancer types, the genetic
basis of Wnt pathway activation remains incompletely understood. Here, we report recurrent …

HER2 is highly expressed in a significant proportion of breast cancer, ovarian cancer, and
gastric cancer. Since the discovery of its role in tumorigenesis, HER2 has received great …

Dynamics of epithelial tissues determine key processes in development, tissue healing and
cancer invasion. These processes are critically influenced by cell–cell adhesion forces …

Brain endothelial cells are unique among endothelial cells in that they express apical
junctional complexes, including tight junctions, which quite resemble epithelial tight …