Studies of mammalian development have advanced our understanding of the genetic,
epigenetic, and cellular processes that orchestrate embryogenesis and have uncovered …

Recent discoveries in stem cell and developmental biology have introduced a new era
marked by the generation of in vitro models that recapitulate early mammalian development …

Recently, several studies using cultures of human embryos together with single-cell RNA-
seq analyses have revealed differences between humans and mice, necessitating the study …

Implantation of the human embryo begins a critical developmental stage that comprises
profound events including axis formation, gastrulation and the emergence of haematopoietic …

With the advancement of human stem cell cultures and interest in understanding human
embryogenesis, human blastocyst-like structures, or human blastoids, are being developed …

In contrast to rodents, the mechanisms underlying human trophectoderm and early placenta
specification are understudied due to ethical barriers and the scarcity of embryos. Recent …

Though totipotency and pluripotency are transient during early embryogenesis, they
establish the foundation for the development of all mammals. Studying these in vivo has …

Stem cells used to model a two-week-old human embryo Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain the …

Human naïve pluripotent stem cells (hnPSCs) can generate integrated models of blastocysts
termed blastoids upon switch to inductive medium. However, the underlying mechanisms …

While studied extensively in model systems, human gastrulation remains obscure. The
scarcity of fetal biological material as well as ethical considerations limit our understanding …