The eukaryotic nucleotide excision repair pathway
RMA Costa, V Chiganças, R da Silva Galhardo… - Biochimie, 2003 - Elsevier
Nucleotide excision repair (NER) is the most versatile mechanism of DNA repair,
recognizing and dealing with a variety of helix-distorting lesions, such as the UV-induced …
recognizing and dealing with a variety of helix-distorting lesions, such as the UV-induced …
How DNA lesions are turned into powerful killing structures: insights from UV-induced apoptosis
LFZ Batista, B Kaina, R Meneghini… - … Research/Reviews in …, 2009 - Elsevier
Mammalian cells treated with ultraviolet (UV) light provide one of the best-known
experimental systems for depicting the biological consequences of DNA damage. UV …
experimental systems for depicting the biological consequences of DNA damage. UV …
[HTML][HTML] Powerful skin cancer protection by a CPD-photolyase transgene
J Jans, W Schul, YG Sert, Y Rijksen, H Rebel… - Current Biology, 2005 - cell.com
Background: The high and steadily increasing incidence of ultraviolet-B (UV-B)-induced skin
cancer is a problem recognized worldwide. UV introduces different types of damage into the …
cancer is a problem recognized worldwide. UV introduces different types of damage into the …
Differential biologic effects of CPD and 6-4PP UV-induced DNA damage on the induction of apoptosis and cell-cycle arrest
HL Lo, S Nakajima, L Ma, B Walter, A Yasui, DW Ethell… - BMC cancer, 2005 - Springer
Background UV-induced damage can induce apoptosis or trigger DNA repair mechanisms.
Minor DNA damage is thought to halt the cell cycle to allow effective repair, while more …
Minor DNA damage is thought to halt the cell cycle to allow effective repair, while more …
A novel microRNA mmu‐miR‐466h affects apoptosis regulation in mammalian cells
A Druz, C Chu, B Majors, R Santuary… - Biotechnology and …, 2011 - Wiley Online Library
This study determined the changes in microRNA (miRs) expression in mammalian Chinese
hamster ovary (CHO) cells undergoing apoptosis induced by exposing the cells to nutrient …
hamster ovary (CHO) cells undergoing apoptosis induced by exposing the cells to nutrient …
CPDs and 6-4PPs play different roles in UV-induced cell death in normal and NER-deficient human cells
KM de Lima-Bessa, MG Armelini, V Chiganças… - DNA repair, 2008 - Elsevier
Ultraviolet (UV) light generates two major DNA lesions: cyclobutane pyrimidine dimers
(CPDs) and pyrimidine-(6-4)-pyrimidone photoproducts (6-4PPs), but the specific …
(CPDs) and pyrimidine-(6-4)-pyrimidone photoproducts (6-4PPs), but the specific …
Pretreatment of ferulic acid protects human dermal fibroblasts against ultraviolet a irradiation
HJ Hahn, KB Kim, S Bae, BG Choi, S An… - Annals of …, 2016 - synapse.koreamed.org
Background Approximately 90%~ 99% of ultraviolet A (UVA) ray reaches the Earth's surface.
The deeply penetrating UVA rays induce the formation of reactive oxygen species (ROS) …
The deeply penetrating UVA rays induce the formation of reactive oxygen species (ROS) …
[HTML][HTML] Transfection of pseudouridine-modified mRNA encoding CPD-photolyase leads to repair of DNA damage in human keratinocytes: A new approach with future …
G Boros, E Miko, H Muramatsu, D Weissman… - … of Photochemistry and …, 2013 - Elsevier
UVB irradiation induces harmful photochemical reactions, including formation of
Cyclobutane Pyrimidine Dimers (CPDs) in DNA. Accumulation of unrepaired CPD lesions …
Cyclobutane Pyrimidine Dimers (CPDs) in DNA. Accumulation of unrepaired CPD lesions …
p53 mutant human glioma cells are sensitive to UV-C-induced apoptosis due to impaired cyclobutane pyrimidine dimer removal
LFZ Batista, WP Roos, B Kaina, CFM Menck - Molecular Cancer Research, 2009 - AACR
The p53 protein is a key regulator of cell responses to DNA damage, and it has been shown
that it sensitizes glioma cells to the alkylating agent temozolomide by up-regulating the …
that it sensitizes glioma cells to the alkylating agent temozolomide by up-regulating the …
Effect of cell confluence on ultraviolet light apoptotic responses in DNA repair deficient cells
H Carvalho, RMA da Costa, V Chiganças… - … Research/Reviews in …, 2003 - Elsevier
One of the major critical factors for cancer proneness is the cell response to DNA damage. In
this work, we used human DNA repair deficient cell lines to investigate the responses to …
this work, we used human DNA repair deficient cell lines to investigate the responses to …