The development of cancer is due to the accumulation of multiple somatic mutations and in
some cases due to germline mutations, which occur in malignancies such as retinoblastoma …

Publisher Summary Carcinoma, cancer of epithelial cells, is a major cause of morbidity and
mortality. Clonal fixation and propagation of oncogenic genetic changes, sporadically …

HER2 or ErbB2 is a member of the epidermal growth factor family and is overexpressed in
subsets of breast, ovarian, gastric, colorectal, pancreatic, and endometrial cancers. HER2 …

In the Western world, endometrial carcinoma is the most common malignant tumour of the
female genital tract and the fourth most common cancer in women after carcinomas of …

Background The incidence of vulvar squamous cell carcinoma (VSCC) has been on the rise
since the 1990s. There has been no new treatment for advanced and recurrent disease in …

Squamous cell carcinomas (SCCs) of the vulva develop through human papilloma virus
(HPV)-associated or HPV-independent pathways, but the relationship between …

Epidermal growth factor receptor (EGFR) levels are dramatically increased in human
keratinocytes (HKc) immortalized with full-length human papillomavirus type 16 (HPV16) …

OBJECTIVE: To evaluate the efficacy and toxicity of erlotinib in the management of
squamous cell carcinoma (SCC) of the vulva. METHODS: Patients with vulvar lesions …

Although the cervix was recognized as an organ entity as early as 4500 BC during the third
Egyptian Dynasty, it was Soranus, in the first century AD, who gave the first accurate …

An engineered antibody fragment (minibody; scFv-CH3γ1 dimer, M r 80 000) specific for
carcinoembryonic antigen (CEA) has previously demonstrated excellent tumor targeting …