Towards a comprehensive understanding of anesthetic mechanisms of action: a decade of discovery
Significant progress has been made in the 21st century towards a comprehensive
understanding of the mechanisms of action of general anesthetics, coincident with progress …
understanding of the mechanisms of action of general anesthetics, coincident with progress …
GABAA receptors as targets for anaesthetics and analgesics and promising candidates to help treat coronavirus infections: A mini‐review
Y Luo, T Balle - Basic & Clinical Pharmacology & Toxicology, 2022 - Wiley Online Library
GABA is a major inhibitory neurotransmitter that regulates the balance between excitatory
and inhibitory circuits in the human nervous system. The GABA receptors are divided into …
and inhibitory circuits in the human nervous system. The GABA receptors are divided into …
Endocrine disruptors of inhibiting testicular 3β-hydroxysteroid dehydrogenase
S Zhang, J Mo, Y Wang, C Ni, X Li, Q Zhu… - Chemico-Biological …, 2019 - Elsevier
Testicular 3β-hydroxysteroid dehydrogenase (HSD3B) is a steroidogenic enzyme,
catalyzing the conversion of 3β-hydroxysteroids into 3-keto-steroids. Two distinct isoforms in …
catalyzing the conversion of 3β-hydroxysteroids into 3-keto-steroids. Two distinct isoforms in …
The m6A mRNA demethylase FTO regulates GnRH secretion in Mn-induced precocious puberty
X Yang, Z Qi, H Yang, J Li, Y Liu, Y Sang, M Li… - Molecular and Cellular …, 2022 - Elsevier
Abstract The GABA A receptor (GABA AR) plays important roles in the regulation of Mn-
induced GnRH secretion in immature female rats. However, the underlying molecular …
induced GnRH secretion in immature female rats. However, the underlying molecular …
Fluorescent microsphere-based strip for sensitive and quantitative detection of etomidate and metomidate
In this research, we used a novel hapten to generate a sensitive monoclonal antibody (mAb)
2C3 that targeted etomidate (ET) and metomidate (MT). We used this mAb to establish a …
2C3 that targeted etomidate (ET) and metomidate (MT). We used this mAb to establish a …
Competitive antagonism of etomidate action by diazepam: in vitro GABAA receptor and in vivo zebrafish studies
M McGrath, H Hoyt, A Pence, SS Jayakar… - …, 2020 - pmc.ncbi.nlm.nih.gov
Background: Recent cryo-electron microscopic imaging studies have shown that in addition
to binding to the classical extracellular benzodiazepine binding site of the α1β3γ2L γ …
to binding to the classical extracellular benzodiazepine binding site of the α1β3γ2L γ …
Behavioral and steroidogenic pharmacology of phenyl ring substituted etomidate analogs in rats
M McGrath, A Hofmann, DE Raines - BMC Pharmacology and Toxicology, 2019 - Springer
Background Cushing's syndrome is an endocrine disorder characterized by the
overproduction of adrenocortical steroids. Steroidogenesis enzyme inhibitors are the …
overproduction of adrenocortical steroids. Steroidogenesis enzyme inhibitors are the …
依托咪酷用千乳腺癌手术的麻醉效果及对患者应激水平和术后苏醒质量的影响.
甘宁， 王爱忠， 李静， 武凯旋… - Progress in Modern …, 2019 - search.ebscohost.com
摘要目的: 探讨依托咪酣用于乳腺癌手术的麻醉效果及对患者应激水平和术后苏醒质量的影响.
方法: 选择我院2017 年7 月~ 2018 年7 月收治的93 例乳腺癌患者, 按随机数字表法分为对照组 …
方法: 选择我院2017 年7 月~ 2018 年7 月收治的93 例乳腺癌患者, 按随机数字表法分为对照组 …
L-3,3',5-triiodothyronine and pregnenolone sulfate inhibit Torpedo nicotinic acetylcholine receptors
The nicotinic acetylcholine receptor (nAChR) is an excitatory pentameric ligand-gated ion
channel (pLGIC), homologous to the inhibitory γ-aminobutyric acid (GABA) type A receptor …
channel (pLGIC), homologous to the inhibitory γ-aminobutyric acid (GABA) type A receptor …