Axonal transport and Alzheimer's disease

GB Stokin, LSB Goldstein - Annu. Rev. Biochem., 2006 - annualreviews.org
In contrast to most eukaryotic cells, neurons possess long, highly branched processes called
axons and dendrites. In large mammals, such as humans, some axons reach lengths of over …

Functional aspects of primary cilia in signaling, cell cycle and tumorigenesis

SG Basten, RH Giles - Cilia, 2013 - Springer
Dysfunctional cilia underlie a broad range of cellular and tissue phenotypes and can
eventually result in the development of ciliopathies: pathologically diverse diseases that …

[HTML][HTML] The proteome of the mouse photoreceptor sensory cilium complex

Q Liu, G Tan, N Levenkova, T Li, EN Pugh Jr… - Molecular & Cellular …, 2007 - Elsevier
Primary cilia play critical roles in many aspects of biology. Specialized versions of primary
cilia are involved in many aspects of sensation. The single photoreceptor sensory cilium …

[HTML][HTML] The sensory cilia of Caenorhabditis elegans.

PN Inglis, G Ou, MR Leroux, JM Scholey - WormBook, 2007 - ncbi.nlm.nih.gov
The non-motile cilium, once believed to be a vestigial cellular structure, is now increasingly
associated with the ability of a wide variety of cells and organisms to sense their chemical …

Retinal dystrophy in Bardet–Biedl syndrome and related syndromic ciliopathies

A Mockel, Y Perdomo, F Stutzmann, J Letsch… - Progress in retinal and …, 2011 - Elsevier
Primary cilia are almost ubiquitously expressed in eukaryotic cells where they function as
sensors relaying information either from the extracellular environment or between two …

The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development

RS Gray, PB Abitua, BJ Wlodarczyk… - Nature cell …, 2009 - nature.com
The planar cell polarity (PCP) signalling pathway is essential for embryonic development
because it governs diverse cellular behaviours, and'core PCP'proteins, such as Dishevelled …

[HTML][HTML] Three-dimensional architecture of the rod sensory cilium and its disruption in retinal neurodegeneration

JC Gilliam, JT Chang, IM Sandoval, Y Zhang, T Li… - Cell, 2012 - cell.com
Defects in primary cilia lead to devastating disease because of their roles in sensation and
developmental signaling but much is unknown about ciliary structure and mechanisms of …

Analysis of the extracellular matrix vesicle proteome in mineralizing osteoblasts

Z Xiao, CE Camalier, K Nagashima… - Journal of cellular …, 2007 - Wiley Online Library
Many key processes central to bone formation and homeostasis require the involvement of
osteoblasts, cells responsible for accumulation and mineralization of the extracellular matrix …

Rootletin interacts with C-Nap1 and may function as a physical linker between the pair of centrioles/basal bodies in cells

J Yang, M Adamian, T Li - Molecular biology of the cell, 2006 - Am Soc Cell Biol
Rootletin, a major structural component of the ciliary rootlet, is located at the basal bodies
and centrosomes in ciliated and nonciliated cells, respectively. Here we investigated its …

Terminal transport of lytic granules to the immune synapse is mediated by the kinesin-1/Slp3/Rab27a complex

M Kurowska, N Goudin, NT Nehme… - Blood, The Journal …, 2012 - ashpublications.org
Cytotoxic T lymphocytes kill target cells via the polarized secretion of cytotoxic granules at
the immune synapse. The lytic granules are initially recruited around the polarized …