State-of-the-art evidence in the treatment of systemic sclerosis

JE Pope, CP Denton, SR Johnson… - Nature Reviews …, 2023 - nature.com
Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease with multi-organ
involvement, fibrosis and vasculopathy. Treatment in SSc, including early diffuse cutaneous …

Interstitial Lung Disease: A Review

TM Maher - JAMA, 2024 - jamanetwork.com
Importance Interstitial lung disease (ILD) consists of a group of pulmonary disorders
characterized by inflammation and/or fibrosis of the lung parenchyma associated with …

Treatment of a patient with severe systemic sclerosis (SSc) using CD19-targeted CAR T cells

C Bergmann, F Müller, JHW Distler, AH Györfi… - Annals of the …, 2023 - ard.bmj.com
Several lines of evidence suggest a role of B cells in severe systemic sclerosis (SSc)
pathophysiology: elevated levels of B-cell stimulating factors, disturbed B-cell homeostasis …

2023 American College of Rheumatology (ACR)/American College of Chest Physicians (CHEST) guideline for the treatment of interstitial lung disease in people with …

SR Johnson, EJ Bernstein, MB Bolster… - Arthritis Care & …, 2024 - Wiley Online Library
Objective We provide evidence‐based recommendations regarding the treatment of
interstitial lung disease (ILD) in adults with systemic autoimmune rheumatic diseases …

Rituximab and mycophenolate mofetil combination in patients with interstitial lung disease (EVER-ILD): a double-blind, randomised, placebo-controlled trial

J Mankikian, A Caille… - European …, 2023 - Eur Respiratory Soc
Background Standard of care for interstitial lung disease (ILD) with a nonspecific interstitial
pneumonia (NSIP) pattern proposes mycophenolate mofetil (MMF) as one of the first-step …

Treatable traits: a comprehensive precision medicine approach in interstitial lung disease

YH Khor, V Cottin, AE Holland, Y Inoue… - European …, 2023 - Eur Respiratory Soc
Interstitial lung disease (ILD) is a diverse group of inflammatory and fibrotic lung conditions
causing significant morbidity and mortality. A multitude of factors beyond the lungs influence …

Systemic sclerosis interstitial lung disease: unmet needs and potential solutions

V Liakouli, A Ciancio, F Del Galdo… - Nature Reviews …, 2024 - nature.com
Systemic sclerosis (SSc), or scleroderma, is a rare, complex, systemic autoimmune disease
of unknown aetiology, characterized by high morbidity and mortality often resulting from …

Mass cytometry identifies characteristic immune cell subsets in bronchoalveolar lavage fluid from interstitial lung diseases

K Hata, T Yanagihara, K Matsubara… - Frontiers in …, 2023 - frontiersin.org
Immune cells have been implicated in interstitial lung diseases (ILDs), although their
phenotypes and effector mechanisms remain poorly understood. To better understand these …

Rituximab in Patients with Systemic Sclerosis–associated Interstitial Lung Disease: A Systematic Review and Meta-Analysis

M Macrea, M Ghazipura, D Herman… - Annals of the …, 2024 - atsjournals.org
Background: The American Thoracic Society convened an international, multidisciplinary
panel to develop clinical practice guidelines for the treatment of systemic sclerosis …

Interstitial lung disease in patients with anti-neutrophil cytoplasm antibody-associated vasculitis: an update on pathogenesis and treatment

D Turgeon, MS Balter, C Pagnoux - Current Opinion in Pulmonary …, 2023 - journals.lww.com
Interstitial lung disease in patients with anti-neutrophil c... : Current Opinion in Pulmonary
Medicine Interstitial lung disease in patients with anti-neutrophil cytoplasm antibody-associated …