The NF-κB (nuclear factor κ-light-chain-enhancer of activated B cells) transcription factor
family is a pleiotropic regulator of many cellular signaling pathways, providing a mechanism …

In the last decades, the search for natural products with biological applications as alternative
treatments for several inflammatory diseases has increased. In this respect, terpenes are a …

Glioblastoma, the most aggressive form of malignant glioma, is very difficult to treat because
of its aggressively invasive nature and high recurrence rates. RAS‐selective lethal 3 (RSL3) …

Acute myocardial infarction (MI) is the leading cause of death worldwide. Exogenous
delivery of nitric oxide (NO) to the infarcted myocardium has proven to be an effective …

Telomeres are the heterochromatic repeat regions at the ends of eukaryotic chromosomes,
whose length is considered to be a determinant of biological ageing. Normal ageing itself is …

Inflammation may be defined as the innate response to harmful stimuli such as pathogens,
injury, and metabolic stress; its ultimate function is to restore the physiological homeostatic …

Hypoxia and inflammation have been associated with a number of pathological conditions,
in particular inflammatory diseases. While hypoxia is mainly associated with the activation of …

At high concentrations, free radicals and radical-derived, nonradical reactive species are
hazardous for living organisms and damage all major cellular constituents. At moderate …

The selective degradation of many short-lived proteins in eukaryotic cells is carried out by
the ubiquitin system. In this pathway, proteins are targeted for degradation by covalent …

Melatonin is a highly evolutionary conserved endogenous molecule that is mainly produced
by the pineal gland, but also by other nonendocrine organs, of most mammals including …