The human immunodeficiency virus type 1 (HIV-1) proteome is expressed from alternatively
spliced and unspliced genomic RNAs. However, HIV-1 RNAs that are not fully spliced are …

Understanding HIV-1 persistence despite antiretroviral therapy (ART) is of paramount
importance. Both single-genome sequencing (SGS) and integration site analysis (ISA) …

Recent advances in the study of virus-cell interactions have improved our understanding of
how viruses that replicate their genomes in the nucleus (eg, retroviruses, hepadnaviruses …

During HIV infection, specific RNA-protein interaction between the Rev response element
(RRE) and viral Rev protein is required for nuclear export of intron-containing viral mRNA …

Abstract Expression of the Human Endogenous Retrovirus Type K (HERV-K), the youngest
and most active HERV, has been associated with various cancers and neurodegenerative …

HIV-1 Rev is an essential viral regulatory protein that facilitates the nuclear export of intron-
containing viral mRNAs. It is organized into structured, functionally well-characterized motifs …

Background: To complete its replication cycle, HIV-1 requires the nucleocytoplasmic export
of intron-containing viral mRNAs. This process is ordinarily restricted by the cell, but HIV …

HIV-1 Rev mediates the nuclear export of unspliced and partially-spliced viral transcripts for
the production of progeny genomes and structural proteins. In this process, four (or more) …

Despite being first identified more than three decades ago, the antisense gene asp of HIV-1
remains an enigma. asp is present uniquely in pandemic (group M) HIV-1 strains, and it is …

The characterisation of the HIV-1 reservoir, which consists of replication-competent
integrated proviruses that persist on antiretroviral therapy (ART), is made difficult by the rarity …