Adenoviruses have transitioned from tools for gene replacement therapy to bona fide
vaccine delivery vehicles. They are attractive vaccine vectors as they induce both innate and …

Replication incompetent human adenovirus serotype 5 (HAdV-C5) has been extensively
used as a delivery vehicle for gene therapy proteins and infectious disease antigens. These …

Adenoviral vectors based on adenovirus type 35 (rAd35) have the advantage of low natural
vector immunity and induce strong, insert-specific T-and B-cell responses, making them …

Vaccine approaches to infectious diseases are widely applied and appreciated. Amongst
them, vectors based on recombinant viruses have shown great promise and play an …

Replication‐defective adenoviruses have been utilized as candidate vaccine vectors.
However, clinical application of the best‐studied human adenovirus type‐5 (AdHu5) is …

Vaccines based on adenovirus (Ad) vectors are currently in development against several
pathogens. However, neutralizing antibodies (NAb) to human adenovirus type 5 (AdHu5) …

The causative agent of severe acute respiratory syndrome (SARS) has been identified as a
new type of coronavirus, SARS-associated coronavirus (SARS-CoV). CD8 T cells play an …

Adenoviral vectors have shown great promise as vaccine carriers and in gene transfer to
correct underlying genetic diseases. Traditionally, cstruction of adenoviral vectors is …

Adenoviral vector has been extensively studied as a vaccine platform because of its ability to
induce potent cellular and humoral immunity. One main advantage of adenoviral vectors is …

ABSTRACT A major obstacle to the use of adenovirus vectors derived from common human
serotypes, such as human adenovirus 5 (AdHu5), is the high prevalence of virus …