Abstract Severe coronavirus disease 2019 (COVID-19) is characterized by systemic hyper-
inflammation, acute respiratory distress syndrome, and multiple organ failure. Cytokine …

Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome
induced by aberrantly activated macrophages and cytotoxic T cells. The primary (genetic) …

The concept of coronavirus disease 2019 (COVID-19)-related cytokine storm syndrome
(COVID-CSS) emerged early in the severe acute respiratory syndrome coronavirus 2 (SARS …

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome describing patients with severe
systemic hyperinflammation. Characteristic features include unremitting fever, cytopenias …

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of pathologic immune activation,
often associated with genetic defects of lymphocyte cytotoxicity. Though a distinctive …

The historic term 'histiocytosis' meaning 'tissue cell'is used as a unifying concept for
diseases characterized by pathogenic myeloid cells that share histological features with …

Abstract The interleukin (IL)-2–IL-2 receptor (IL-2R) pathway is important in immunity, but is
also involved in maintenance of self-tolerance. This paradox is further complicated by …

Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening state of immune
hyperactivation that arises in the setting of genetic mutations and infectious, inflammatory, or …

A subset of patients with severe COVID-19 develop profound inflammation and multi-organ
dysfunction consistent with a “Cytokine Storm Syndrome”(CSS). In this review we compare …

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening inflammatory syndrome that
may complicate hematologic malignancies (HMs). The appropriateness of current criteria for …