Intestinal stem cells at the bottom of crypts fuel the rapid renewal of the different cell types
that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of …

The intestinal epithelium withstands continuous mechanical, chemical and biological insults
despite its single-layered, simple epithelial structure. The crypt–villus tissue architecture in …

Many important cell types in adult vertebrates have a mesenchymal origin, including
fibroblasts and vascular mural cells. Although their biological importance is undisputed, the …

Intestinal mesenchymal cells play essential roles in epithelial homeostasis, matrix
remodeling, immunity, and inflammation. But the extent of heterogeneity within the colonic …

Determining the epigenetic program that generates unique cell types in the kidney is critical
for understanding cell-type heterogeneity during tissue homeostasis and injury response …

Intestinal stem cells (ISCs) are confined to crypt bottoms and their progeny differentiate near
crypt-villus junctions. Wnt and bone morphogenic protein (BMP) gradients drive this polarity …

A fundamental function of the intestinal epithelium is to act as a barrier that limits interactions
between luminal contents such as the intestinal microbiota, the underlying immune system …

Tissues that undergo rapid cellular turnover, such as the mammalian haematopoietic system
or the intestinal epithelium, are dependent on stem and progenitor cells that proliferate to …

Barrier epithelia depend upon resident stem cells for homeostasis, defense, and repair.
Epithelial stem cells of small and large intestines (ISCs) respond to their local …

Intestinal stem and progenitor cells replicate and differentiate in distinct compartments,
influenced by Wnt, BMP, and other subepithelial cues. The cellular sources of these signals …