Environmental chemicals have significant impacts on biological systems. Chemical
exposures during early stages of development can disrupt normal patterns of development …

The ability of environmental factors to promote a phenotype or disease state not only in the
individual exposed but also in subsequent progeny for successive generations is termed …

Epigenetics refers to heritable changes that are not encoded in the DNA sequence itself, but
play an important role in the control of gene expression. In mammals, epigenetic …

Previous observations have demonstrated that embryonic exposure to the endocrine
disruptor vinclozolin during gonadal sex determination promotes transgenerational adult …

Background and aim A large number of chemical compounds with endocrine-disrupting
activity have been documented. These chemicals are ubiquitous and widely used in many …

Dietary exposures can have consequences for health years or decades later and this raises
questions about the mechanisms through which such exposures are 'remembered'and how …

Although uterine leiomyomata (fibroids) have been the leading indication for hysterectomy in
the United States for decades, the epidemiological data on fibroid prevalence and risk …

This review focuses on how environmental factors through epigenetics modify disease risk
and health outcomes. Major epigenetic events, such as histone modifications, DNA …

Cancer, as one of the non-communicable diseases, remains one of the leading causes of
death around the world. Recently, epigenetic changes in DNA methylation patterns at CpG …

The endocrine disruptor vinclozolin has previously been shown to promote epigenetic
transgenerational inheritance of adult onset disease in the rat. The current study was …