Computational vaccinology includes epitope mapping, antigen selection, and immunogen
design using computational tools. Tools that facilitate the in silico prediction of immune …

Protein therapeutics hold a prominent and rapidly expanding place among medicinal
products. Purified blood products, recombinant cytokines, growth factors, enzyme …

Monkeypox is a self-limiting zoonotic viral disease and causes smallpox-like symptoms. The
disease has a case fatality ratio of 3–6% and, recently, a multi-country outbreak of the …

Computational vaccine design, also known as computational vaccinology, encompasses
epitope mapping, antigen selection and immunogen design using computational tools. The …

In the course of screening immunoglobulin G (IgG) sequences for T cell epitopes, we
identified novel Treg epitope peptides, now called Tregitopes, contained in the highly …

In 1796, Edward Jenner introduced the concept of vaccination with cowpox virus, an
Orthopoxvirus within the family Poxviridae that elicits cross protective immunity against …

HLA class II‐restricted regulatory T cell (Treg) epitopes in IgG (also called “Tregitopes”) have
been reported to suppress immune responses to coadministered antigens by stimulating the …

Smallpox has shaped human history, from the earliest human civilizations well into the 20th
century. With high mortality rates, rapid transmission, and serious long-term effects on …

Influenza world-wide causes significant morbidity and mortality annually, and more severe
pandemics when novel strains evolve to which humans are immunologically naïve. Because …

Helicobacter pylori is the leading cause of gastritis, peptic ulcer disease and gastric
adenocarcinoma and lymphoma in humans. Due to the decreasing efficacy of anti-H. pylori …