Inflammation is an evolutionarily selected defense response to infection or tissue damage
that involves activation and consumption of immune cells in order to reestablish and …

The morbidity and mortality of HIV type-1 (HIV-1)-related diseases were dramatically
diminished by the grounds of the introduction of potent antiretroviral therapy, which induces …

The persistence of latent reservoir of the human immunodeficiency virus (HIV) is currently
the major challenge in curing HIV infection. After HIV infects the human body, the latent HIV …

Type I interferons (IFN) can have dual and opposing roles in immunity, with effects that are
beneficial or detrimental to the individual depending on whether IFN pathway activation is …

HIV-1 persists indefinitely in people living with HIV (PLWH) on antiretroviral therapy (ART). If
ART is stopped, the virus rapidly rebounds from long-lived latently infected cells. Using a …

Following the discovery of plasmacytoid dendritic cells (pDCs) and of their extraordinary
ability to produce type I IFNs (IFN-I) in response to TLR7 and TLR9 stimulation, it is assumed …

Acquired immunodeficiency syndrome (AIDS), caused by the human immunodeficiency
virus (HIV), has become a heavy burden of disease and an important public health problem …

Latent reservoirs in human-immunodeficiency-virus-1 (HIV-1)-infected individuals represent
a major obstacle in finding a cure for HIV-1. Hematopoietic stem and progenitor cells …

Chronic anemia is more prevalent in people living with HIV (PLWH) compared to the general
population. The mechanisms that drive chronic anemia in HIV are multifaceted and include …

Mucosal-associated invariant T (MAIT) cells in HIV-1–infected individuals are functionally
impaired by poorly understood mechanisms. Single-cell transcriptional and surface protein …