Fluorine, often called as “a small atom with a big ego”, 1 lies in the second row and the 17th
column in the periodic table of the chemical elements. This unique position in the periodic …

The relevance of the‐CF2H moiety has attracted considerable attention from organic
synthetic and medicinal chemistry communities, because this group can act as a more …

Electrophilic trifluoromethylation reactions have been the latest approach to achieve the
fluoroalkylation of compounds with newly‐discovered reagents, such as the Togni's (1 …

Owing to the excellent performance of fluorinated compounds in the areas of
pharmaceuticals, agrochemicals, and materials chemistry, organic chemists have made …

The incorporation of fluorine-containing moieties into organic compounds is of great
importance in pharmaceutical, agricultural, and materials science. Transition-metal …

Transition-metal-mediated fluoroalkylation is a hot research topic in current organofluorine
chemistry. In the past five years, due to the development of new perfluoroalkylation reagents …

A Pd (0)-catalyzed intramolecular aryldifluoromethylation of activated alkenes under mild
reaction conditions has been developed. This reaction provides a new method for …

One way to introduce fluorine into a molecule is through fluoroalkylation reactions.
Transition-metal catalysts play an increasing role in selectively incorporating fluoroalkyl …

An atom-economical method for radical (phenylsulfonyl) difluoromethylation of isocyanides
with PhSO2CF2H under transition-metal-free conditions has been developed. A PhSO2CF2 …

A copper-mediated trifluoromethylation of propargylic halides and trifluoroacetates was
performed with high allenyl or propargyl selectivity. The reaction proceeds smoothly with …