Beyond the rule of 5: lessons learned from AbbVie's drugs and compound collection: miniperspective

DA DeGoey, HJ Chen, PB Cox… - Journal of medicinal …, 2017 - ACS Publications
Recently, there has been an increasing focus on the pursuit of targets considered to be less
druggable that offer potential for development of promising new therapeutic agents for the …

HCV in Egypt, prevention, treatment and key barriers to elimination

M El Kassas, T Elbaz, A Elsharkawy… - Expert review of anti …, 2018 - Taylor & Francis
Introduction: Currently, direct-acting antivirals (DAAs) are considered the ideal choice for the
treatment of chronic HCV patients due to their proven efficacy (SVR> 90%), and minimal …

Study of changes in lipid profile and insulin resistance in Egyptian patients with chronic hepatitis C genotype 4 in the era of DAAs

G El Sagheer, E Soliman, A Ahmad, L Hamdy - Libyan Journal of Medicine, 2018 - ajol.info
Chronic hepatitis C virus (HCV) infection is associated with altered metabolism, including
dyslipidemia and insulin resistance. These contribute to disease progression and influences …

[HTML][HTML] Prehabilitation prior to intestinal resection in Crohn's disease patients: An opinion review

MTJ Bak, MFE Ruiterkamp, O van Ruler… - World Journal of …, 2022 - ncbi.nlm.nih.gov
Patients with Crohn's disease (CD) are at a considerable risk for intestinal surgery.
Approximately 25% of patients with CD will undergo an intestinal resection within 10 years …

Hepatocellular carcinoma and hepatitis C virus treatments: The bold and the beautiful

W Abdelhamed, M El‐Kassas - Journal of Viral Hepatitis, 2023 - Wiley Online Library
The occurrence of hepatocellular carcinoma (HCC) is one of the most serious complications
of hepatitis C virus (HCV) infection. Recently, effective antiviral medications have made …

An account of the real-life hepatitis C management in a single specialized viral hepatitis treatment centre in Egypt: results of treating 7042 patients with 7 different …

M El Kassas, M Alboraie, D Omran… - Expert Review of …, 2018 - Taylor & Francis
Background: A large Egyptian treatment program for HCV was launched in2014 after the
introduction of direct-acting antiviral agents (DAAs). This program depended mainly on …

[HTML][HTML] Fibrosis regression following hepatitis C antiviral therapy

A Elsharkawy, R Samir, M El-Kassas - World Journal of Hepatology, 2022 - ncbi.nlm.nih.gov
Hepatitis C virus (HCV) infection is one of the most common causes of liver pathology. It is a
major etiological factor of continuous liver injury by triggering an uncontrolled inflammatory …

Effectiveness of ravidasvir plus sofosbuvir in interferon-naïve and treated patients with chronic hepatitis C genotype-4

G Esmat, T Elbaz, M El Raziky, A Gomaa… - Journal of …, 2018 - Elsevier
Background & Aims Although treatment of hepatitis C virus (HCV) and HCV-genotype-4
(GT4) has become very effective, it remains very expensive, and affordable options are …

A significant upsurge of body mass index in patients with chronic hepatitis C successfully treated with direct-acting antiviral regimens

M El Kassas, M Alboraie, M Naguib… - The Turkish Journal …, 2018 - pmc.ncbi.nlm.nih.gov
Background/Aims There is less data regarding the changes in body mass index (BMI) after
treating hepatitis C virus (HCV) patients with new direct-acting antiviral agents (DAAs). This …

Mass screening for hepatitis B and C in Southern Upper Egypt

G Soliman, MS Elzalabany, T Hassanein, FDW Miller - BMC public health, 2019 - Springer
Background It is well documented that Egypt has the highest prevalence of hepatitis C virus
(HCV) infection in the world. The recent development of highly effective direct acting antiviral …