Flaviviruses are enveloped single positive-stranded RNA viruses. The capsid (C), a
structural protein of flavivirus, is dimeric and alpha-helical, with several special structural …

Abstract Development of a suitable animal model for dengue virus disease is critical for
understanding pathogenesis and for preclinical testing of antiviral drugs and vaccines. Many …

During a large scale clinical efficacy trial of the Sanofipasteur live-attenuated tetravalent
dengue vaccine (Dengvaxia), features of hospitalized disease accompanying dengue …

Antiviral antibodies constitute an important component of the host immune response against
viral infections and serve to neutralize and reduce infectivity of the virus. However, these …

Background Canine circovirus is a deadly pathogen of dogs and causes vasculitis and
hemorrhagic enteritis. It causes lethal gastroenteritis in pigs, fox, and dogs. Canine …

Background. Each year dengue virus (DENV) infects 400 million human but causes
symptomatic disease in only a subset of patients, suggesting that host genetic factors may …

A broad diversity of arthropod‐borne viruses (arboviruses) of global health concern are
endemic to East Africa, yet most surveillance efforts are limited to just a few key viral …

Dengue is a major global disease requiring improved treatment and prevention strategies.
The recently licensed Sanofi Pasteur Dengvaxia vaccine does not protect children under the …

Dengue is considered the most important emerging, human arboviruses, with worldwide
distribution in the tropics. Unfortunately, there are no licensed dengue vaccines available or …

Newly proposed candidate Zika virus vaccines might or might not succeed in raising safe,
effective, and durable protection against human Zika virus infections or syndromes …