Recent progress in human genetics and single cell sequencing rapidly expands the list of
molecular factors that offer important new contributions to our understanding of brain wiring …

Receptor guanylyl cyclases (GCs) are single membrane spanning, multidomain enzymes,
that synthesize cGMP in response to natriuretic peptides or other ligands. They are …

Activating mutations in the fibroblast growth factor receptor 3 (FGFR3) or inactivating
mutations in guanylyl cyclase–B (GC-B), also known as NPR-B or Npr2, cause short-limbed …

C-type natriuretic peptide (CNP) activation of guanylyl cyclase (GC)-B, also known as NPR2,
stimulates cGMP synthesis and bone elongation. CNP activation requires the …

The natriuretic peptide receptors NPR1 and NPR2, also known as guanylyl cyclase A and
guanylyl cyclase B, have critical functions in many signaling pathways, but much remains …

The retinal degeneration protein RD3 is involved in regulatory processes of photoreceptor
cells. Among its main functions is the inhibition of photoreceptor specific membrane …

C-type natriuretic peptide (CNP) activation of guanylyl cyclase-B (GC-B) catalyzes the
synthesis of cGMP in chondrocytes and osteoblasts. Elevated cGMP stimulates long bone …

C-type natriuretic peptide (CNP) is highly expressed in the central nervous system (CNS)
and key to neuronal development; however, a broader role for CNP in the CNS remains …

The spiral ganglion neurons (SGNs) are the primary afferent neurons in the spiral ganglion
(SG), while their degeneration or loss would cause sensorineural hearing loss. As a cardiac …

Natriuretic peptides and their receptors are implicated in the physiological control of blood
pressure, bone growth, and cardiovascular and renal homeostasis. They mediate their …