Proteases are signaling molecules that specifically control cellular functions by cleaving
protease-activated receptors (PARs). The four known PARs are members of the large family …

Mast cells are best recognized for their role in allergy and anaphylaxis, but increasing
evidence supports their role in neurogenic inflammation leading to pain and itch. Mast cells …

Chronic pain is a major challenge to clinical practice and basic science. The peripheral and
central neural networks that mediate nociception show extensive plasticity in pathological …

Rosacea is a common chronic inflammatory skin disease of the central facial skin and is of
unknown origin. Currently, two classifications of rosacea exist that are based on either …

In a large proportion of individuals nervous system damage may lead to a debilitating
chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder …

Background & Aims: The mechanisms underlying abdominal pain perception in irritable
bowel syndrome (IBS) are poorly understood. Intestinal mast cell infiltration may perturb …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

The neurobiology of itch, which is formally known as pruritus, and its interaction with pain
have been illustrated by the complexity of specific mediators, itch-related neuronal pathways …

The coagulation cascade and protease‐activated receptors (PARs) together provide an
elegant mechanism that links mechanical information in the form of tissue injury to cellular …

Abstract Ossovskaya, Valeria S., and Nigel W. Bunnett. Protease-Activated Receptors:
Contribution to Physiology and Disease. Physiol Rev 84: 579–621, 2004; 10.1152/physrev …