The voltage-dependent anion channel 1 (VDAC1) protein, is an important regulator of
mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for …

Mitochondria are multifunctional and dynamic organelles deeply integrated into cellular
physiology and metabolism. Disturbances in mitochondrial function are involved in several …

The neurotransmitter acetylcholine (ACh) acts as an autocrine growth factor for human lung
cancer. Several lines of evidence show that lung cancer cells express all of the proteins …

Frequent diseases of the CNS, such as Alzheimer's disease, Parkinson's disease, multiple
sclerosis, and psychiatric disorders (eg, schizophrenia), elicit a neuroinflammatory response …

Nicotinic acetylcholine receptors (nAChRs) have long been considered to solely mediate
neurotransmission. However, their widespread distribution in the human body suggests a …

Nicotine in tobacco is known to induce tumor-promoting effects and cause chemotherapy
resistance through the activation of nicotinic acetylcholine receptors (nAChRs). Many …

Nicotinic acetylcholine receptors mediate fast synaptic transmission in neuro-muscular
junctions and autonomic ganglia and modulate survival, proliferation and neurotransmitter …

Microglia, the innate immune cells of the brain, are commonly perceived as resident
macrophages of the central nervous system (CNS). This definition, however, requires further …

Stem cells provide a sensitive model to study exposure to toxicants, such as cigarette
smoke. Electronic cigarettes (ECs) are popular nicotine delivery devices, often targeted to …

An established contribution of neuroinflammation to multiple brain pathologies has raised
the requirement for therapeutic strategies to overcome it in order to prevent age-and disease …