Polycystic ovarian syndrome (PCOS) is a prevailing endocrine and metabolic disorder
occurring in about 6–20% of females in reproductive age. Most symptoms of PCOS arise …

Ever since the brain was identified as an insulin-sensitive organ, evidence has rapidly
accumulated that insulin action in the brain produces multiple behavioral and metabolic …

Physiologically important cell-signalling networks are complex, and contain several points of
regulation, signal divergence and crosstalk with other signalling cascades. Here, we use the …

Alzheimer's disease (AD) is the most common form of dementia affecting elderly people. AD
is a multifaceted pathology characterized by accumulation of extracellular neuritic plaques …

This review will provide insight on the current understanding of the regulation of insulin
signaling in both physiological and pathological conditions through modulations that occur …

Since the discovery of the beneficial effects of adrenocortical extracts for treating adrenal
insufficiency more than 80 years ago, glucocorticoids (GC) and their cognate, intracellular …

Genome-wide association studies have identified common variants that only partially
explain the genetic risk for type 2 diabetes (T2D). Using genome-wide association data from …

Despite remarkable progress in dissecting the signaling pathways that are crucial for the
metabolic effects of insulin, the molecular basis for the specificity of its cellular actions is not …

Insulin-stimulated glucose uptake in adipose tissue and striated muscle is critical for
reducing post-prandial blood glucose concentrations and the dysregulation of this process is …

Insulin resistance is a feature of a number of clinical disorders, including type 2
diabetes/glucose intolerance, obesity, dyslipidaemia and hypertension clustering in the so …