The enteric nervous system controls much of the mixing and propulsion of nutrients along
the digestive tract. Enteric neural circuits involve intrinsic sensory neurons, interneurons and …

The biology of H2S is a still developing area of research and several biological functions
have been recently attributed to this gaseous molecule in many physiological systems …

Normal motility of the colon is critical for quality of life and efforts to normalize abnormal
colon function have had limited success. A better understanding of control systems of …

Key points• Neural‐mediated relaxation occurs in the gastrointestinal tract. To accomplish
this function, two neurotransmitters, ATP or a related purine and nitric oxide, are released by …

Key points• A new class of interstitial cells, PDGFRα+ cells, is distributed densely in the
proximal stomachs of mice.• PDGFRα+ cells express the molecular apparatus necessary for …

Nitric oxide (NO) is a major inhibitory neurotransmitter in the gastrointestinal (GI) tract. Its
main effector, NO-sensitive guanylyl cyclase (NO-GC), is expressed in several GI cell types …

The etiology of diarrhea-predominant irritable bowel syndrome (IBS-D) is complicated and
closely related to neurotransmission in the gastrointestinal (GI) tract. Developing new …

Methods We retrospectively reviewed the records of all patients with chronic dyspeptic
symptoms and constipation who underwent both a solid gastric emptying scintigraphy and a …

Key points Platelet derived growth factor receptor α (PDGFRα+) cells in colonic muscles are
innervated by enteric inhibitory motor neurons. PDGFRα+ cells generate Ca2+ transients in …

Background and Aims Better understanding of intrinsic control mechanisms of colonic
motility will lead to better treatment options for colonic dysmotility. The aim was to investigate …