Janus tyrosine kinase (JAK) family of proteins have been identified as crucial proteins in
signal transduction initiated by a wide range of membrane receptors. Among the proteins in …

Abstract The Janus kinases (JAKs) and signal transducer and activator of transcription
(STAT) proteins, particularly STAT3, are among the most promising new targets for cancer …

Background Metastasis is the main cause of death in colorectal cancer (CRC). Circulating
tumour cells (CTCs) are regarded as the precursor cells of metastasis. The CTCs, which …

The gastrointestinal microbiota has come to the fore in the search for the causes of IBD. This
shift has largely been driven by the finding of genetic polymorphisms involved in …

Abstract Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor
with many important functions in the biology of normal and transformed cells. Its regulation is …

Signal transducer and activator of transcription 3 (STAT3) is one of the crucial transcription
factors, responsible for regulating cellular proliferation, cellular differentiation, migration …

Signal transducer and activator of transcription (STAT) 3 is a key signalling protein engaged
by a multitude of growth factors and cytokines to elicit diverse biological outcomes including …

Intercellular communication between tumor cells, immune cells and the stroma characterises
the tumor microenvironment, which is instrumental for establishing the ecological niche that …

Background Aberrant activation of STAT3 is frequently encountered and promotes survival,
cellular proliferation, migration, invasion and angiogenesis in tumor cell. Convallatoxin …

Simple Summary Many signaling pathways are overactive in breast cancer, and among
them is the STAT3 signaling pathway. STAT3 is activated by secreted factors within the …