Clinical relevance of donor‐specific antibodies directed at HLA‐C: a long road to acceptance

J Visentin, L Couzi, JL Taupin - HLA, 2021 - Wiley Online Library
In solid organ transplantation (SOT), the clinical relevance of donor‐specific antibodies
(DSA) directed at anti‐HLA‐A,‐B,‐DR and‐DQ antigens is largely recognized while it is still …

Interchain disulfide engineering enables the efficient production of functional HLA-DQ-Fc fusion proteins

X Aisihaer, H Guo, C Liu - Journal of Biological Chemistry, 2024 - jbc.org
HLA-DQ molecules drive unwanted alloimmune responses after solid-organ transplants and
several autoimmune diseases, including type 1 diabetes and celiac disease. Biologics with …

A Curious Case of Anti-Human Leukocyte Antigen-Bw4 Antibody in a Kidney Transplant Candidate

MM Ibrahim, M Shen, M Merzkani… - The journal of applied …, 2023 - academic.oup.com
A 49-year-old White female with end-stage renal disease was referred to our medical center
for evaluation as a kidney transplant candidate. Her past medical history was remarkable for …

Association of Bw4/Bw6 mismatch across class I HLA loci with renal graft outcomes in first time transplants

M San Tang, M Wang, SH Chang, T Alhamad, C Liu - Human Immunology, 2021 - Elsevier
Bw4 and Bw6 are strongly immunogenic epitopes routinely assigned based on HLA-B
typing results per Organ Procurement and Transplantation Network (OPTN) policies. These …

Case report: Successful simultaneous heart-kidney transplantation across a positive complement-dependent cytotoxic crossmatch

T Yamamoto, DS Pearson, EI Ababneh… - Frontiers in …, 2022 - frontiersin.org
Preformed donor-specific antibodies are associated with a higher risk of rejection and worse
graft survival in organ transplantation. However, in heart transplantation, the risk and benefit …

[HTML][HTML] A curious case of de novo anti-HLA-C antibody-mediated humoral rejection and Fabry-like zebra bodies in a renal transplant recipient

M Abuzeineh, A Ziadeh, T Kheradmand… - Clinical nephrology …, 2020 - ncbi.nlm.nih.gov
Detection of donor-specific antibodies (DSA) is an essential part of diagnosing antibody-
mediated renal allograft rejection (ABMR). The role of solitary preformed, or post-transplant …