Matching chelators to radiometals for radiopharmaceuticals

EW Price, C Orvig - Chemical Society Reviews, 2014 - pubs.rsc.org
Radiometals comprise many useful radioactive isotopes of various metallic elements. When
properly harnessed, these have valuable emission properties that can be used for …

Radioactive transition metals for imaging and therapy

E Boros, AB Packard - Chemical reviews, 2018 - ACS Publications
Nuclear medicine is composed of two complementary areas, imaging and therapy. Positron
emission tomography (PET) and single-photon imaging, including single-photon emission …

Coordinating radiometals of copper, gallium, indium, yttrium, and zirconium for PET and SPECT imaging of disease

TJ Wadas, EH Wong, GR Weisman… - Chemical …, 2010 - ACS Publications
Molecular imaging is the visualization, characterization, and measurement of biological
processes at the molecular and cellular levels in humans and other living systems …

Comparison of 64Cu-Complexing Bifunctional Chelators for Radioimmunoconjugation: Labeling Efficiency, Specific Activity, and in Vitro/in Vivo Stability

MS Cooper, MT Ma, K Sunassee, KP Shaw… - Bioconjugate …, 2012 - ACS Publications
High radiolabeling efficiency, preferably to high specific activity, and good stability of the
radioimmunoconjugate are essential features for a successful immunoconjugate for imaging …

Recent developments in the design of bifunctional chelators for metal-based radiopharmaceuticals used in Positron Emission Tomography

MD Bartholomä - Inorganica Chimica Acta, 2012 - Elsevier
In recent years, Positron Emission Tomography (PET) has become a practical, high
performance clinical imaging modality for visualization of biological process within the living …

Toward personalized medicine: One chelator for imaging and therapy with lutetium-177 and actinium-225

P Cieslik, M Kubeil, K Zarschler, M Ullrich… - Journal of the …, 2022 - ACS Publications
We report a nonadentate bispidine (3, 7-diazabicyclo [3.3. 1] nonane) that unveils the
potential to bind theranostically relevant radionuclides, including indium-111, lutetium-177 …

Bombesin receptor-mediated imaging and cytotoxicity: review and current status

V Sancho, A Di Florio, TW Moody… - Current drug …, 2011 - ingentaconnect.com
The three mammalian bombesin (Bn) receptors (gastrin-releasing peptide [GRP] receptor,
neuromedin B [NMB] receptor, BRS-3) are one of the classes of G protein-coupled receptors …

Peptide-based positron emission tomography probes: Current strategies for synthesis and radiolabelling

M Failla, G Floresta, V Abbate - RSC Medicinal Chemistry, 2023 - pubs.rsc.org
In medical imaging, techniques such as magnetic resonance imaging, contrast-enhanced
computerized tomography, and positron emission tomography (PET) are extensively …

Radiometallated peptides for molecular imaging and targeted therapy

JDG Correia, A Paulo, PD Raposinho, I Santos - Dalton Transactions, 2011 - pubs.rsc.org
In developed countries, cancer is the second leading cause of death, being only surpassed
by cardiovascular diseases. To develop tumor-targeted tools to localize and treat cancer at …

Emerging chelators for nuclear imaging

D Sneddon, B Cornelissen - Current Opinion in Chemical Biology, 2021 - Elsevier
Chelators are necessary in nuclear medicine imaging to direct an inorganic radionuclide, a
radiometal, to a desired target; unfortunately, there is no 'one-size-fits-all'chelator. As the …