Induced pluripotent stem cell (iPSC)-based disease modelling and the cell replacement
therapy approach have proven to be very powerful and instrumental in biomedical research …

Reprogramming to induced pluripotent stem cells (iPSCs) proceeds in a stepwise manner
with reprogramming factor binding, transcription, and chromatin states changing during …

Stem cells are undifferentiated cells and have multi-lineage differentiation potential.
Generally, stem cells are classified into adult stem cells, embryonic stem cells (ESCs) and …

Bladder cancer causes an estimated 150,000 deaths per year worldwide. Although 15% of
the recurrent bladder cancer becomes an invasive type, currently used targeted therapy for …

Abstract miRNAs are small non-coding RNAs that have emerged as crucial post-
transcriptional regulators of gene expression. They are key players in various critical cellular …

Stem cells hold great promise for regenerative medicine and the treatment of cardiovascular
diseases. The mechanisms regulating self-renewal, pluripotency, and differentiation are not …

Abstract Derivation of induced Pluripotent Stem Cells (iPSCs) by reprogramming somatic
cells to a pluripotent state has revolutionized stem cell research. Ensuing this, various …

The human heart has a limited capacity to regenerate lost or damaged cardiomyocytes after
cardiac insult. Instead, myocardial injury is characterized by extensive cardiac remodeling …

Lineage conversion has recently attracted increasing attention as a potential alternative to
the directed differentiation of pluripotent cells to obtain cells of a given lineage. Different …

miR‐372/373, a cluster of stem cell‐specific micro RNA s transactivated by the Wnt pathway,
has been reported to be dysregulated in various cancers, particularly colorectal cancer …