Abstract Curcumin (diferuloylmethane or 1, 7-bis (4-hydroxy-3-methoxyphenyl)-1, 6-
heptadiene-3, 5-dione) is an interesting compound that is characterized by a special …

Curcumin is a pharmacologically active polyphenol derived from the popular spice element-
Turmeric. The therapeutic activity of curcumin has been extensively investigated over the …

Curcumin, a naturally occurring compound found in the rhizome of Curcuma plants,
particularly in turmeric (Curcuma longa L.), exhibits a broad range of biological activities …

Currently, particular focus is placed on the implication of autophagy in a variety of human
diseases, including cancer. Discovery of small-molecule modulators of autophagy as well as …

It has been extensively verified that inflammation and oxidative stress play important roles in
the pathogenesis of cardiovascular diseases (CVDs). Curcuminoids, from the plant Curcuma …

To understand complex biological processes, scientists must gain insight into the function of
individual living cells. In contrast to the imaging of fixed cells, where a single snapshot of the …

This report summarizes the latest published data on the antiproliferative action and cytotoxic
activity of Mannich bases, a structurally heterogeneous category of chemical entities that …

ABSTRACT Introduction: The versatile multicomponent Mannich reaction occupies a salient
position in organic chemistry and drug design. Sound knowledge of its scope and variations …

Achiral Mannich-type curcumin analogs have been synthetized and assayed for their
cytotoxic activity. The anti-proliferative and cytotoxic activity of curcuminoids has been tested …

The synthesis and characterization of a series of donor‐π‐acceptor‐π‐donor (D‐A‐D)
curcuminoid molecules is presented herein that incorporates π‐extended aryl and electron …