The discovery of induced pluripotent stem cells (iPSCs) has made an invaluable contribution
to the field of regenerative medicine, paving way for identifying the true potential of human …

Background Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have
emerged as a powerful tool for disease modeling, though their immature nature currently …

Osteoarthritis (OA) is a low‐grade inflammatory and progressive joint disease, and its
progression is closely associated with an imbalance in M1/M2 synovial macrophages …

The advent of induced pluripotent stem cells (iPSCs) has advanced our understanding of the
molecular mechanisms of human disease, drug discovery, and regenerative medicine. As …

Mitochondria control life and death in eukaryotic cells. Harboring a unique circular genome,
a by‐product of an ancient endosymbiotic event, mitochondria maintains a specialized and …

Hypertrophic cardiomyopathy (HCM) is the most prominent cause of sudden cardiac death
in young people. Due to heterogeneity in clinical manifestations, conventional HCM drugs …

Cardiovascular diseases (CVDs) are a class of disorders affecting the heart or blood
vessels. Despite progress in clinical research and therapy, CVDs still represent the leading …

Human-induced pluripotent stem cells (hiPSC) can be differentiated to cardiomyocytes at
high efficiency and are increasingly used to study cardiac disease in a human context. This …

Auditory neuropathy spectrum disorder (ANSD) is a hearing impairment caused by
dysfunction of inner hair cells, ribbon synapses, spiral ganglion neurons and/or the auditory …

One of the obstacles in studying the pathogenesis of hypertrophic cardiomyopathy (HCM) is
the poor availability of myocardial tissue samples at the early stages of disease …