Base editing—the introduction of single-nucleotide variants (SNVs) into DNA or RNA in
living cells—is one of the most recent advances in the field of genome editing. As around …

CRISPR/Cas9 genome editing has gained rapidly increasing attentions in recent years,
however, the translation of this biotechnology into therapy has been hindered by efficient …

The discovery of clustered regularly interspaced short palindromic repeats (CRISPR)
genome editing technology opened the door to provide a versatile approach for treating …

Recent advances in genome editing technologies have magnified the prospect of single-
dose cures for many genetic diseases. For most genetic disorders, precise DNA correction is …

Prolonged expression of the CRISPR-Cas9 nuclease and gRNA from viral vectors may
cause off-target mutagenesis and immunogenicity. Thus, a transient delivery system is …

Extracellular vesicles (EVs) have shown promise as biological delivery vehicles, but
therapeutic applications require efficient cargo loading. Here, we developed new methods …

The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system has
revolutionized the field of gene editing. Continuous efforts in developing this technology …

Transient delivery of CRISPR‐based genome editing effectors is important to reduce off‐
target effects and immune responses. Recently extracellular vesicles (EVs) have been …

Therapeutic genome editing requires effective and targeted delivery methods. The delivery
of Cas9 mRNA using adeno-associated viruses has led to potent in vivo therapeutic efficacy …

Extracellular vesicles (EVs) have emerged as biocompatible drug delivery vehicles due to
their native ability to deliver bioactive cargo to recipient cells. However, the application of …