LRPPRC: a multifunctional protein involved in energy metabolism and human disease

J Cui, L Wang, X Ren, Y Zhang, H Zhang - Frontiers in physiology, 2019 - frontiersin.org
The pentatricopeptide repeat (PPR) family plays a major role in RNA stability, regulation,
processing, splicing, translation, and editing. Leucine-rich PPR-motif-containing protein …

Targeting mitochondrial protein expression as a future approach for cancer therapy

D Criscuolo, R Avolio, DS Matassa, F Esposito - Frontiers in Oncology, 2021 - frontiersin.org
Extensive metabolic remodeling is a fundamental feature of cancer cells. Although early
reports attributed such remodeling to a loss of mitochondrial functions, it is now clear that …

[HTML][HTML] LRPPRC regulates redox homeostasis via the circANKHD1/FOXM1 axis to enhance bladder urothelial carcinoma tumorigenesis

WS Wei, N Wang, M Deng, P Dong, J Liu, Z Xiang… - Redox Biology, 2021 - Elsevier
Reactive oxygen species (ROS) which are continuously generated mainly by mitochondria,
have been proved to play an important role in the stress signaling of cancer cells. Moreover …

A traditional gynecological medicine inhibits ovarian cancer progression and eliminates cancer stem cells via the LRPPRC–OXPHOS axis

R Jiang, Z Chen, M Ni, X Li, H Ying, J Fen… - Journal of Translational …, 2023 - Springer
Background Ovarian cancer (OC) is the most lethal malignant gynecological tumor type for
which limited therapeutic targets and drugs are available. Enhanced mitochondrial oxidative …

Mitochondrial‐Related Transcriptome Feature Correlates with Prognosis, Vascular Invasion, Tumor Microenvironment, and Treatment Response in Hepatocellular …

Y Wang, F Song, X Zhang… - Oxidative Medicine and …, 2022 - Wiley Online Library
Background. Hepatocellular carcinoma (HCC) is the most common subtype of primary liver
cancer, which was highly correlated with metabolic dysfunction. Nevertheless, the …

m6A‐Mediated Tumor Invasion and Methylation Modification in Breast Cancer Microenvironment

F Liu, X Yu, G He - Journal of oncology, 2021 - Wiley Online Library
Background. We analyzed the n6‐methyladenosine (m6A) modification patterns of immune
cells infiltrating the tumor microenvironment of breast cancer (BC) to provide a new …

Autophagy inhibitor LRPPRC suppresses mitophagy through interaction with mitophagy initiator Parkin

J Zou, F Yue, W Li, K Song, X Jiang, J Yi, L Liu - PloS one, 2014 - journals.plos.org
Autophagy plays an important role in tumorigenesis. Mitochondrion-associated protein
LRPPRC interacts with MAP1S that interacts with LC3 and bridges autophagy components …

A/(H1N1) pdm09 NS1 promotes viral replication by enhancing autophagy through hijacking the IAV negative regulatory factor LRPPRC

X Guo, Z Zhang, C Lin, H Ren, Y Li, Y Zhang, Y Qu… - Autophagy, 2023 - Taylor & Francis
The quadrilateral reassortant IAV A/(H1N1) pdm09 is the pathogen responsible for the first
influenza pandemic of the 21st century. The virus spread rapidly among hosts causing high …

Gene promoter-associated CpG island hypermethylation in squamous cell carcinoma of the tongue

S Bhat, SP Kabekkodu, C Jayaprakash… - Virchows Archiv, 2017 - Springer
The present study was undertaken to explore and validate novel hypermethylated DNA
regions in squamous cell carcinoma of the tongue (SCCT). Genome-wide methylation …

LRPPRC inhibits autophagy and promotes foam cell formation in atherosclerosis

Z Xu, X Li, Z Ding, Y Zhang, Z Peng, X Yang… - The FEBS …, 2022 - Wiley Online Library
Lipid‐laden macrophages are considered as the main source of foam cells in
atherosclerosis; however, the mechanism for macrophage foam cell formation remains …