Novel therapeutic targets in depression: minocycline as a candidate treatment

JK Soczynska, RB Mansur, E Brietzke… - Behavioural brain …, 2012 - Elsevier
Mood disorders are marked by high rates of non-recovery, recurrence, and chronicity, which
are insufficiently addressed by current therapies. Several patho-etiological models have …

Dysregulated neuronal–microglial cross-talk during aging, stress and inflammation

HA Jurgens, RW Johnson - Experimental neurology, 2012 - Elsevier
Communication between neurons and microglia is essential for maintaining homeostasis in
the central nervous system (CNS) during both physiological and inflammatory conditions …

Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration

L Zhao, MK Zabel, X Wang, W Ma, P Shah… - EMBO molecular …, 2015 - embopress.org
Retinitis pigmentosa, caused predominantly by mutations in photoreceptor genes, currently
lacks comprehensive treatment. We discover that retinal microglia contribute non‐cell …

Long-term neuroinflammation induced by influenza A virus infection and the impact on hippocampal neuron morphology and function

S Hosseini, E Wilk, K Michaelsen-Preusse… - Journal of …, 2018 - Soc Neuroscience
Acute influenza infection has been reported to be associated with neurological symptoms.
However, the long-term consequences of an infection with neurotropic and non-neurotropic …

[HTML][HTML] Gut microbiota indole-3-propionic acid mediates neuroprotective effect of probiotic consumption in healthy elderly: A randomized, double-blind, placebo …

CS Kim, S Jung, GS Hwang, DM Shin - Clinical Nutrition, 2023 - Elsevier
Background & aims The beneficial effects of probiotic consumption on age-related decline in
cerebral function have been previously reported in the literature; however, the mechanistic …

Kaempferol acts through mitogen‐activated protein kinases and protein kinase B/AKT to elicit protection in a model of neuroinflammation in BV2 microglial cells

SE Park, K Sapkota, S Kim, H Kim… - British journal of …, 2011 - Wiley Online Library
BACKGROUND AND PURPOSE Kaempferol, a dietary flavonoid and phyto‐oestrogen, is
known to have anti‐inflammatory properties. Microglial activation has been implicated in …

(−)‐Epigallocatechin gallate inhibits lipopolysaccharide‐induced microglial activation and protects against inflammation‐mediated dopaminergic neuronal injury

R Li, YG Huang, D Fang, WD Le - Journal of neuroscience …, 2004 - Wiley Online Library
Microglial activation is believed to play a pivotal role in the selective neuronal injury
associated with several neurodegenerative disorders, including Parkinson's disease (PD) …

Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity

KR Byrnes, B Stoica, DJ Loane, A Riccio, MI Davis… - Glia, 2009 - Wiley Online Library
The Group I metabotropic glutamate receptor 5 (mGluR5) can modulate addiction, pain, and
neuronal cell death. Expression of some mGluRs, such as Group II and III mGluRs, has been …

Nitric oxide as a physiopathological factor in neuropsychiatric disorders

O Akyol, SS Zoroglu, F Armutcu, S Sahin, A Gurel - In vivo, 2004 - iv.iiarjournals.org
The dominant research subject on schizophrenia, mood disorders, autism and other central
nervous system diseases has been related to neurotransmitter system abnormalities. For …

Microglia induce neural cell death via a proximity-dependent mechanism involving nitric oxide

HM Gibbons, M Dragunow - Brain research, 2006 - Elsevier
Microglial cells play a major role in the pathogenesis of many neurological diseases by
exacerbating neuronal and non-neuronal cell death, but the mechanisms involved are …