Current perspective of pathophysiological and interventional effects on endothelial progenitor cell biology: focus on PI3K/AKT/eNOS pathway

BR Everaert, EM Van Craenenbroeck… - International journal of …, 2010 - Elsevier
For more than a decade, endothelial progenitor cells (EPCs) have been implicated in
cardiovascular homeostasis. EPCs are believed to reside within the bone marrow in close …

Blood vessels and peripheral nerves as key players in cancer progression and therapy resistance

N Roda, G Blandano, PG Pelicci - Cancers, 2021 - mdpi.com
Simple Summary The interactions between cancer cells and the surrounding blood vessels
and peripheral nerves are critical in all the phases of tumor development. Accordingly …

Effect of increased exercise in school children on physical fitness and endothelial progenitor cells: a prospective randomized trial

C Walther, L Gaede, V Adams, G Gelbrich, A Leichtle… - Circulation, 2009 - Am Heart Assoc
Background—The aim of this prospective, randomized study was to examine whether
additional school exercise lessons would result in improved peak oxygen uptake (primary …

Decreased number and impaired functionality of endothelial progenitor cells in subjects with metabolic syndrome: implications for increased cardiovascular risk

I Jialal, S Devaraj, U Singh, BA Huet - Atherosclerosis, 2010 - Elsevier
OBJECTIVE: Metabolic syndrome (MetS) is characterized by low-grade inflammation and
confers an increased risk for cardiovascular disease. Endothelial progenitor cells (EPCs) are …

[HTML][HTML] Circulating endothelial and progenitor cells: Evidence from acute and long-term exercise effects

M Koutroumpi, S Dimopoulos, K Psarra… - World Journal of …, 2012 - ncbi.nlm.nih.gov
Circulating bone-marrow-derived cells, named endothelial progenitor cells (EPCs), are
capable of maintaining, generating, and replacing terminally differentiated cells within their …

Assessment of endothelial dysfunction in childhood obesity and clinical use

L Bruyndonckx, VY Hoymans… - Oxidative Medicine …, 2013 - Wiley Online Library
The association of obesity with noncommunicable diseases, such as cardiovascular
complications and diabetes, is considered a major threat to the management of health care …

The Long Telling Story of “Endothelial Progenitor Cells”: Where Are We at Now?

MC Vinci, E Carulli, E Rurali, R Rinaldi, G Damiano… - Cells, 2022 - mdpi.com
Endothelial progenitor cells (EPCs): The name embodies years of research and clinical
expectations, but where are we now? Do these cells really represent the El Dorado of …

Exercise training with dietary restriction enhances circulating irisin level associated with increasing endothelial progenitor cell number in obese adults: an intervention …

J Huang, S Wang, F Xu, D Wang, H Yin, Q Lai, J Liao… - PeerJ, 2017 - peerj.com
Objective Circulating endothelial progenitor cells (EPCs) correlate negatively with obesity.
Previous studies have shown that exercise significantly restores circulating EPC levels in …

METRNL exerts cytoprotective effects on EPCs via regulation of the E2F1-TXNIP axis in obese limb ischemia

J Li, Z Ge, C Li, H Ran, Y Zhang, Y Xiang - Cellular Signalling, 2025 - Elsevier
Background Obesity increases cardiovascular disease risk by impairing angiogenesis,
primarily through dysfunction of endothelial progenitor cells (EPCs). METRNL, a recently …

Endothelial progenitor cells in vascular health: focus on lifestyle

EM Van Craenenbroeck, VM Conraads - Microvascular Research, 2010 - Elsevier
Endothelial dysfunction, which is considered the functional equivalent of a disrupted
balance between endothelial injury and repair, precedes overt atherosclerosis by many …