Current and novel biomarkers of thrombotic risk in COVID-19: a consensus statement from the international COVID-19 thrombosis biomarkers colloquium

DA Gorog, RF Storey, PA Gurbel, US Tantry… - Nature Reviews …, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) predisposes patients to thrombotic and
thromboembolic events, owing to excessive inflammation, endothelial cell activation and …

Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?

SE Engelen, AJB Robinson, YX Zurke… - Nature Reviews …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …

Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19

A Bonaventura, A Vecchié, L Dagna… - Nature Reviews …, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is a clinical syndrome caused by infection
with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with severe …

Interplay between inflammation and thrombosis in cardiovascular pathology

K Stark, S Massberg - Nature Reviews Cardiology, 2021 - nature.com
Thrombosis is the most feared complication of cardiovascular diseases and a main cause of
death worldwide, making it a major health-care challenge. Platelets and the coagulation …

Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome

EA Middleton, XY He, F Denorme… - Blood, The Journal …, 2020 - ashpublications.org
COVID-19 affects millions of patients worldwide, with clinical presentation ranging from
isolated thrombosis to acute respiratory distress syndrome (ARDS) requiring ventilator …

NETworking with cancer: The bidirectional interplay between cancer and neutrophil extracellular traps

JM Adrover, SAC McDowell, XY He, DF Quail… - Cancer Cell, 2023 - cell.com
Neutrophils are major effectors and regulators of the immune system. They play critical roles
not only in the eradication of pathogens but also in cancer initiation and progression …

[HTML][HTML] Viral presence and immunopathology in patients with lethal COVID-19: a prospective autopsy cohort study

B Schurink, E Roos, T Radonic, E Barbe… - The Lancet …, 2020 - thelancet.com
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) targets
multiple organs and causes severe coagulopathy. Histopathological organ changes might …

The emerging threat of (micro) thrombosis in COVID-19 and its therapeutic implications

JD McFadyen, H Stevens, K Peter - Circulation research, 2020 - Am Heart Assoc
The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing global pandemic has presented a health emergency of unprecedented …

Signaling pathways and intervention therapies in sepsis

Y Zhang, B Ning - Signal Transduction and Targeted Therapy, 2021 - nature.com
Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

Hypercoagulability of COVID‐19 patients in intensive care unit: a report of thromboelastography findings and other parameters of hemostasis

M Panigada, N Bottino, P Tagliabue… - … of thrombosis and …, 2020 - Wiley Online Library
Background The severe inflammatory state secondary to COVID‐19 leads to a severe
derangement of hemostasis that has been recently described as a state of disseminated …