Synthetic glycans to improve current glycoconjugate vaccines and fight antimicrobial resistance

L Del Bino, KE Østerlid, DY Wu, F Nonne… - Chemical …, 2022 - ACS Publications
Antimicrobial resistance (AMR) is emerging as the next potential pandemic. Different
microorganisms, including the bacteria Acinetobacter baumannii, Clostridioides difficile …

Nanobiotics against antimicrobial resistance: harnessing the power of nanoscale materials and technologies

N Chakraborty, D Jha, I Roy, P Kumar… - Journal of …, 2022 - Springer
Given the spasmodic increment in antimicrobial resistance (AMR), world is on the verge of
“post-antibiotic era”. It is anticipated that current SARS-CoV2 pandemic would worsen the …

Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications

CD Spicer, C Jumeaux, B Gupta… - Chemical Society …, 2018 - pubs.rsc.org
Peptide–and protein–nanoparticle conjugates have emerged as powerful tools for
biomedical applications, enabling the treatment, diagnosis, and prevention of disease. In …

Discovery of semi-and fully-synthetic carbohydrate vaccines against bacterial infections using a medicinal chemistry approach: focus review

PH Seeberger - Chemical Reviews, 2021 - ACS Publications
The glycocalyx, a thick layer of carbohydrates, surrounds the cell wall of most bacterial and
parasitic pathogens. Recognition of these unique glycans by the human immune system …

Immunological properties of gold nanoparticles

LA Dykman, NG Khlebtsov - Chemical science, 2017 - pubs.rsc.org
In the past decade, gold nanoparticles have attracted strong interest from the
nanobiotechnological community owing to the significant progress made in robust and easy …

Multivalent glycoconjugates as anti-pathogenic agents

A Bernardi, J Jiménez-Barbero, A Casnati… - Chemical Society …, 2013 - pubs.rsc.org
Multivalency plays a major role in biological processes and particularly in the relationship
between pathogenic microorganisms and their host that involves protein–glycan recognition …

Development of Next Generation Streptococcus pneumoniae Vaccines Conferring Broad Protection

M Masomian, Z Ahmad, L Ti Gew, CL Poh - Vaccines, 2020 - mdpi.com
Streptococcus pneumoniae is a major pathogen causing pneumonia with over 2 million
deaths annually, especially in young children and the elderly. To date, at least 98 different …

Glyconanoparticles as multifunctional and multimodal carbohydrate systems

M Marradi, F Chiodo, I García, S Penadés - Chemical Society Reviews, 2013 - pubs.rsc.org
The quest for the construction of multivalent carbohydrate systems, with precise geometries
that are highly efficient in interacting with carbohydrate binding proteins, has been a goal of …

Nanoparticle–protein corona complexes govern the biological fates and functions of nanoparticles

C Gunawan, M Lim, CP Marquis, R Amal - Journal of Materials …, 2014 - pubs.rsc.org
Upon contact with plasma or other protein-containing biological fluids, the surface of
nanoparticles is immediately decorated with proteins forming a biologically active protein …

Glycoconjugate vaccines: current approaches towards faster vaccine design

F Micoli, L Del Bino, R Alfini, F Carboni… - Expert review of …, 2019 - Taylor & Francis
Introduction: Over the last decades, glycoconjugate vaccines have been proven to be a
successful strategy to prevent infectious diseases. Many diseases remain to be controlled …