Advances in ovarian cancer therapy

AJ Cortez, P Tudrej, KA Kujawa… - Cancer chemotherapy and …, 2018 - Springer
Epithelial ovarian cancer is typically diagnosed at an advanced stage. Current state-of-the-
art surgery and chemotherapy result in the high incidence of complete remissions; however …

Quercetin and cancer: new insights into its therapeutic effects on ovarian cancer cells

A Vafadar, Z Shabaninejad, A Movahedpour, F Fallahi… - Cell & bioscience, 2020 - Springer
Ovarian cancer is known as a serious malignancy that affects women's reproductive tract
and can considerably threat their health. A wide range of molecular mechanisms and …

Evaluating cell lines as tumour models by comparison of genomic profiles

S Domcke, R Sinha, DA Levine, C Sander… - Nature …, 2013 - nature.com
Cancer cell lines are frequently used as in vitro tumour models. Recent molecular profiles of
hundreds of cell lines from The Cancer Cell Line Encyclopedia and thousands of tumour …

Cell origins of high-grade serous ovarian cancer

J Kim, EY Park, O Kim, JM Schilder, DM Coffey… - Cancers, 2018 - mdpi.com
High-grade serous ovarian cancer, also known as high-grade serous carcinoma (HGSC), is
the most common and deadliest type of ovarian cancer. HGSC appears to arise from the …

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

KM Nieman, HA Kenny, CV Penicka, A Ladanyi… - Nature medicine, 2011 - nature.com
Intra-abdominal tumors, such as ovarian cancer,, have a clear predilection for metastasis to
the omentum, an organ primarily composed of adipocytes. Currently, it is unclear why tumor …

Chemotherapy resistance in epithelial ovarian cancer: Mechanisms and emerging treatments

C Marchetti, F De Felice, A Romito, V Iacobelli… - Seminars in Cancer …, 2021 - Elsevier
Ovarian cancer (OC) remains a fatal malignancy because most patients experience
recurrent disease, which is resistant to chemotherapy. The outcomes for patients with …

Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers

BG Bitler, KM Aird, A Garipov, H Li, M Amatangelo… - Nature medicine, 2015 - nature.com
The gene encoding ARID1A, a chromatin remodeler, shows one of the highest mutation
rates across many cancer types. Notably, ARID1A is mutated in over 50% of ovarian clear …

Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer—shifting the paradigm

RJ Kurman, IM Shih - Human pathology, 2011 - Elsevier
Recent morphologic, immunohistochemical, and molecular genetic studies have led to the
development of a new paradigm for the pathogenesis and origin of epithelial ovarian cancer …

Imaging and photodynamic therapy: mechanisms, monitoring, and optimization

JP Celli, BQ Spring, I Rizvi, CL Evans… - Chemical …, 2010 - ACS Publications
The purpose of this review is to present the current state of the role of imaging in
photodynamic therapy (PDT). For the reader to fully appreciate the context of the discussions …

The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory

RJ Kurman, IM Shih - The American journal of surgical pathology, 2010 - journals.lww.com
Ovarian cancer is the most lethal gynecologic malignancy. Efforts at early detection and new
therapeutic approaches to reduce mortality have been largely unsuccessful, because the …