The transcriptional coactivators CREB-binding protein (CBP) and p300 undergo a
particularly rich set of interactions with disordered and partly ordered partners, as a part of …

Gene-specific transcription factors (TFs) are key regulatory components of signaling
pathways, controlling, for example, cell growth, development, and stress responses. Their …

Intrinsically disordered proteins (IDPs) are characterized by a lack of persistent structure.
Since their identification more than a decade ago, many questions regarding their functional …

Allosteric regulatory processes are implicated at all levels of biological function. Recent
advances in our understanding of the diverse and functionally significant class of intrinsically …

Protein–protein interactions (PPI) are involved in all cellular processes and many represent
attractive therapeutic targets. However, the frequently rather flat and large interaction areas …

The kinase-inducible domain interacting (KIX) domain is a highly conserved independently
folding three-helix bundle that serves as a docking site for transcription factors, whereupon …

Intrinsically disordered proteins often become structured upon interacting with their partners.
The mechanism of this 'folding upon binding'process, however, has not been fully …

Summary Double homeobox 4 (DUX4) is expressed at the early pre-implantation stage in
human embryos. Here we show that induced human DUX4 expression substantially alters …

The last five years have witnessed major developments in the understanding of the allosteric
phenomenon, broadly defined as coupling between remote molecular sites. Such advances …

Intrinsically disordered proteins (IDP s) are closely related to various human diseases.
Because IDP s lack certain tertiary structure, it is difficult to use X‐ray and NMR methods to …