Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors

K Onomoto, K Onoguchi, M Yoneyama - Cellular & molecular …, 2021 - nature.com
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …

Comparative structure and function analysis of the RIG-I-like receptors: RIG-I and MDA5

M Brisse, H Ly - Frontiers in immunology, 2019 - frontiersin.org
RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated
protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of …

RIG-I and other RNA sensors in antiviral immunity

KT Chow, M Gale Jr, YM Loo - Annual review of immunology, 2018 - annualreviews.org
Pattern recognition receptors (PRRs) survey intra-and extracellular spaces for pathogen-
associated molecular patterns (PAMPs) within microbial products of infection. Recognition …

TRIM proteins and their roles in antiviral host defenses

M van Gent, KMJ Sparrer, MU Gack - Annual review of virology, 2018 - annualreviews.org
Tripartite motif (TRIM) proteins are a versatile family of ubiquitin E3 ligases involved in a
multitude of cellular processes. Studies in recent years have demonstrated that many TRIM …

Signaling through nucleic acid sensors and their roles in inflammatory diseases

H Okude, D Ori, T Kawai - Frontiers in Immunology, 2021 - frontiersin.org
Recognition of pathogen-derived nucleic acids by pattern-recognition receptors (PRRs) is
essential for eliciting antiviral immune responses by inducing the production of type I …

TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing

GJ Seo, C Kim, WJ Shin, EH Sklan, H Eoh… - Nature …, 2018 - nature.com
Intracellular nucleic acid sensors often undergo sophisticated modifications that are critical
for the regulation of antimicrobial responses. Upon recognition of DNA, the cytosolic sensor …

Insights into the Antiviral Immunity against Grass Carp (Ctenopharyngodon idella) Reovirus (GCRV) in Grass Carp

Y Rao, J Su - Journal of Immunology Research, 2015 - Wiley Online Library
Global fish production from aquaculture has rapidly grown over the past decades, and grass
carp shares the largest portion. However, hemorrhagic disease caused by grass carp …

Mitochondrial DNA-triggered innate immune response: mechanisms and diseases

MM Hu, HB Shu - Cellular & Molecular Immunology, 2023 - nature.com
Various cellular stress conditions trigger mitochondrial DNA (mtDNA) release from
mitochondria into the cytosol. The released mtDNA is sensed by the cGAS-MITA/STING …

TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization

W Gao, Y Li, X Liu, S Wang, P Mei, Z Chen… - Cell Death & …, 2022 - nature.com
Abstract Gasdermin-D (GSDMD), the executioner of pyroptotic cell death when it is cleaved
by inflammatory caspases, plays a crucial role in host defense and the response to danger …

Intracellular sensing of viral genomes and viral evasion

HC Lee, K Chathuranga, JS Lee - Experimental & molecular medicine, 2019 - nature.com
During viral infection, virus-derived cytosolic nucleic acids are recognized by host
intracellular specific sensors. The efficacy of this recognition system is crucial for triggering …