Population studies have shown that among all the genetic factors linked with autoimmune
disease development, MHC class II genes on chromosome 6 accounts for majority of familial …

Type 1 diabetes is a multifactorial disease in which the insulin producing β‐cells of the
pancreas are destroyed by the immune system, a process determined by the activity of major …

Current HIV vaccine approaches are focused on immunogens encoding whole HIV
antigenic proteins that mainly elicit cytotoxic CD8+ responses. Mounting evidence points …

To define the role of semaphorin 4A (Sema4A) in allergic response, we employed
Sema4A−/− and wild-type (WT) mice in the experimental model of ovalbumin (OVA)-induced …

Th2 cells induce asthma through the secretion of cytokines. Two such cytokines, IL-4 and IL-
13, are critical mediators of many features of this disease. They both share a common …

Streptococcus pyogenes infections remain a health problem in several countries because of
post-streptococcal sequelae, such as rheumatic fever and rheumatic heart disease. We …

BACKGROUND: Short ragweed and giant ragweed pollen allergens are considered largely
cross-reactive, and it is generally believed that 1 species is sufficient for skin testing and …

Specific HLA DQ and DR alleles have been associated with susceptibility to type 1 diabetes.
HLA DQ8 and DQ2 have been shown to strongly predispose to disease and to be in linkage …

The human leukocyte antigen (HLA) restriction of the IgE response to different allergens in
humans has been a subject of numerous published studies. However, the role and …

Abstract Neuroimmune semaphorin 4A (Sema4A) has been shown to play an important
costimulatory role in T cell activation and regulation of Th1-mediated diseases such as …