Tumour necrosis factor (TNF) is a central cytokine in inflammatory reactions, and biologics
that neutralize TNF are among the most successful drugs for the treatment of chronic …

Since the discovery of the nuclear factor kappa B (NF-ĸB) transcription factor 36 years ago,
many studies have linked the NF-ĸB signaling pathway to pathological and physiological …

We report the updated classification of inborn errors of immunity, compiled by the
International Union of Immunological Societies Expert Committee. This report documents the …

Systemic autoinflammatory diseases (SAIDs) are a heterogeneous group of disorders
caused by excess activation of the innate immune system in an antigen-independent …

The balance between a protective and a destructive immune response can be precarious,
as exemplified by inborn errors in nucleotide metabolism. This class of inherited disorders …

Inborn errors of immunity (IEIs) are immunological disorders characterized by variable
susceptibility to infections, immune dysregulation and/or malignancies, as a consequence of …

Significance: Oxidative stress (OS) and inflammation are inducers of tissue injury. Alternative
splicing (AS) is an essential regulatory step for diversifying the eukaryotic proteome. Human …

While inflammation induced by Toll-like receptor (TLR) signaling is required to combat
infection, persistent inflammation can damage host tissues and contribute to a myriad of …

Systemic autoinflammatory diseases are a heterogeneous group of rare genetic disorders
caused by dysregulation of the innate immune system. Understanding the complex …

Update on autoinflammatory diseases : Current Opinion in Rheumatology Update on
autoinflammatory diseases : Current Opinion in Rheumatology Log in or Register Subscribe to …