Neuroinflammation in HIV-associated depression: Evidence and future perspectives

A Mudra Rakshasa-Loots, HC Whalley, JH Vera… - Molecular …, 2022 - nature.com
People living with HIV face a high risk of mental illness, especially depression. We do not yet
know the precise neurobiological mechanisms underlying HIV-associated depression …

Depression and HIV: a scoping review in search of neuroimmune biomarkers

A Mudra Rakshasa-Loots - Brain Communications, 2023 - academic.oup.com
People with HIV are at increased risk for depression, though the neurobiological
mechanisms underlying this are unclear. In the last decade, there has been a substantial …

Cognitive health in persons with human immunodeficiency virus: the impact of early treatment, comorbidities, and aging

HL Aung, J Alagaratnam, P Chan… - The Journal of …, 2023 - academic.oup.com
With the advent of virally suppressive antiretroviral therapy (ART), life expectancy for
persons with human immunodeficiency virus (HIV) with access to ART now approaches that …

Higher soluble CD163 in blood is associated with significant depression symptoms in men with HIV

AM Anderson, F Bhondoekhan… - JAIDS Journal of …, 2022 - journals.lww.com
Background: People with HIV (PWH) are more likely to experience depression, a highly
morbid disease. More evidence is needed to better understand mechanisms of depression …

Depressive-like behavior is accompanied by prefrontal cortical innate immune fatigue and dendritic spine losses after HIV-1 tat and morphine exposure

SR Nass, YK Hahn, M Ohene-Nyako, VD McLane… - Viruses, 2023 - mdpi.com
Opioid use disorder (OUD) and HIV are comorbid epidemics that can increase depression.
HIV and the viral protein Tat can directly induce neuronal injury within reward and …

[HTML][HTML] Anterior insula activation during cardiac interoception relates to depressive symptom severity in HIV-positive and HIV-negative postmenopausal women

RC McIntosh, JD Lobo, M Reed… - Psychosomatic …, 2022 - journals.lww.com
Objective This study aimed to determine whether subclinical symptoms of depression in
postmenopausal women are associated with blood oxygen level–dependent (BOLD) activity …

Neopterin relates to lifetime depression in older adults with HIV on suppressive antiretroviral therapy

R Saloner, N Savini, SL Letendre… - JAIDS Journal of …, 2022 - journals.lww.com
Background: Chronic inflammation contributes to the pathogenesis of depression in persons
with HIV (PWH). Neopterin, a biomarker of HIV-related immune activation that partially …

[HTML][HTML] Accelerated aging in people living with HIV: The neuroimmune feedback model

JM Schrock - Brain, Behavior, & Immunity-Health, 2024 - Elsevier
People living with HIV (PLWH) experience earlier onset of aging-related comorbidities
compared to their counterparts without HIV. This paper lays out a theoretical model to …

Verbal memory performance and depressive symptoms in persons with treated HIV

L Xu, MJ Gill, C Power, E Fujiwara - AIDS and Behavior, 2023 - Springer
The link between memory and comorbid depression in persons with HIV (PWH) is unclear
based on evidence from published cohorts. We compared verbal memory in the HVLT-R in a …

Neurocognition and its predictors in a linguistically and culturally diverse cohort of people with HIV

J Breton, CWM Watson, L Kamalyan… - The Clinical …, 2024 - Taylor & Francis
Objective: HIV/AIDS disproportionately affects Black and Latino people in the United States,
yet there is a lack of research on predictors of neurocognitive outcomes in these groups. We …