Evolution of circadian rhythms: from bacteria to human
The human body persists in its rhythm as per its initial time zone, and transition always occur
according to solar movements around the earth over 24 h. While traveling across different …
according to solar movements around the earth over 24 h. While traveling across different …
Transcriptional control of circadian rhythms and metabolism: a matter of time and space
All biological processes, living organisms, and ecosystems have evolved with the Sun that
confers a 24-hour periodicity to life on Earth. Circadian rhythms arose from evolutionary …
confers a 24-hour periodicity to life on Earth. Circadian rhythms arose from evolutionary …
[HTML][HTML] The genomic landscape and pharmacogenomic interactions of clock genes in cancer chronotherapy
Cancer chronotherapy, treatment at specific times during circadian rhythms, endeavors to
optimize anti-tumor effects and to lower toxicity. However, comprehensive characterization of …
optimize anti-tumor effects and to lower toxicity. However, comprehensive characterization of …
Ras-mediated deregulation of the circadian clock in cancer
Circadian rhythms are essential to the temporal regulation of molecular processes in living
systems and as such to life itself. Deregulation of these rhythms leads to failures in biological …
systems and as such to life itself. Deregulation of these rhythms leads to failures in biological …
Feedback loops of the mammalian circadian clock constitute repressilator
Mammals evolved an endogenous timing system to coordinate their physiology and
behaviour to the 24h period of the solar day. While it is well accepted that circadian rhythms …
behaviour to the 24h period of the solar day. While it is well accepted that circadian rhythms …
Specificity in circadian clock feedback from targeted reconstitution of the NuRD corepressor
Mammalian circadian rhythms are generated by a negative feedback loop in which PERIOD
(PER) proteins accumulate, form a large nuclear complex (PER complex), and bind the …
(PER) proteins accumulate, form a large nuclear complex (PER complex), and bind the …
[HTML][HTML] Circadian systems biology: When time matters
The circadian clock is a powerful endogenous timing system, which allows organisms to fine-
tune their physiology and behaviour to the geophysical time. The interplay of a distinct set of …
tune their physiology and behaviour to the geophysical time. The interplay of a distinct set of …
A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery
L Lande-Diner, C Boyault, JY Kim… - Proceedings of the …, 2013 - National Acad Sciences
Circadian clocks in mammals are built on a negative feedback loop in which the
heterodimeric transcription factor circadian locomotor output cycles kaput (CLOCK)-brain …
heterodimeric transcription factor circadian locomotor output cycles kaput (CLOCK)-brain …
Ube3a imprinting impairs circadian robustness in Angelman syndrome models
S Shi, TJ Bichell, RA Ihrie, CH Johnson - Current Biology, 2015 - cell.com
Background The paternal allele of Ube3a is silenced by imprinting in neurons, and
Angelman syndrome (AS) is a disorder arising from a deletion or mutation of the maternal …
Angelman syndrome (AS) is a disorder arising from a deletion or mutation of the maternal …
[HTML][HTML] Chemical chronobiology: toward drugs manipulating time
T Wallach, A Kramer - FEBS letters, 2015 - Elsevier
Circadian clocks are endogenous timing systems orchestrating the daily regulation of a
huge variety of physiological, metabolic and behavioral processes. These clocks are …
huge variety of physiological, metabolic and behavioral processes. These clocks are …