The cancer-immunity cycle: Indication, genotype, and immunotype

I Mellman, DS Chen, T Powles, SJ Turley - Immunity, 2023 - cell.com
The cancer-immunity cycle provides a framework to understand the series of events that
generate anti-cancer immune responses. It emphasizes the iterative nature of the response …

CAR T cell therapy for patients with solid tumours: key lessons to learn and unlearn

SM Albelda - Nature Reviews Clinical Oncology, 2024 - nature.com
Chimeric antigen receptor (CAR) T cells have been approved for use in patients with B cell
malignancies or relapsed and/or refractory multiple myeloma, yet efficacy against most solid …

Lymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: the phase 1 AMPLIFY-201 trial

S Pant, ZA Wainberg, CD Weekes, M Furqan… - Nature medicine, 2024 - nature.com
Pancreatic and colorectal cancers are often KRAS mutated and are incurable when tumor
DNA or protein persists or recurs after curative intent therapy. Cancer vaccine ELI-002 2P …

CAR-T and CAR-NK as cellular cancer immunotherapy for solid tumors

L Peng, G Sferruzza, L Yang, L Zhou… - Cellular & Molecular …, 2024 - nature.com
In the past decade, chimeric antigen receptor (CAR)-T cell therapy has emerged as a
promising immunotherapeutic approach for combating cancers, demonstrating remarkable …

Self-Adjuvanting Polyguanidine Nanovaccines for Cancer Immunotherapy

X Zhang, K Wang, Z Zhao, X Shan, Y Wang, Z Feng… - ACS …, 2024 - ACS Publications
Tapping into the innate immune system's power, nanovaccines can induce tumor-specific
immune responses, which is a promising strategy in cancer immunotherapy. However …

Current advances in cancer vaccines targeting NY-ESO-1 for solid cancer treatment

H Zhou, Y Ma, F Liu, B Li, D Qiao, P Ren… - Frontiers in …, 2023 - frontiersin.org
New York-esophageal cancer 1 (NY-ESO-1) belongs to the cancer testis antigen (CTA)
family, and has been identified as one of the most immunogenic tumor-associated antigens …

Effect of structural features on the antitumor activity of plant and microbial polysaccharides: A review

S Li, Z Zhao, Z He, J Yang, Y Feng, Y Xu, Y Wang, B He… - Food Bioscience, 2024 - Elsevier
With the lifestyle change and environmental pollution, tumors have become one of the most
serious diseases that threaten human health. However, therapeutic and drug resistances …

Arming CAR-T cells with cytokines and more: Innovations in the fourth-generation CAR-T development

L Tang, S Pan, X Wei, X Xu, Q Wei - Molecular Therapy, 2023 - cell.com
Chimeric antigen receptor T cells (CAR-T) therapy has shown great potential in tumor
treatment. However, many factors impair the efficacy of CAR-T therapy, such as antigenic …

Glioblastoma vaccines: past, present, and opportunities

Z Xiong, I Raphael, M Olin, H Okada, X Li… - …, 2024 - thelancet.com
Glioblastoma (GBM) is one of the most lethal central nervous systems (CNS) tumours in
adults. As supplements to standard of care (SOC), various immunotherapies improve the …

Vaccines for immune tolerance against autoimmune disease

A Kim, F Xie, OA Abed, JJ Moon - Advanced drug delivery reviews, 2023 - Elsevier
The high prevalence and rising incidence of autoimmune diseases have become a
prominent public health issue. Autoimmune disorders result from the immune system …