Regulation of Phospholipid Synthesis in the Yeast Saccharomyces cerevisiae
The yeast Saccharomyces cerevisiae, with its full complement of organelles, synthesizes
membrane phospholipids by pathways that are generally common to those found in higher …
membrane phospholipids by pathways that are generally common to those found in higher …
From yeast to humans–roles of the Kennedy pathway for phosphatidylcholine synthesis
CR McMaster - FEBS letters, 2018 - Wiley Online Library
The major phospholipid present in most eukaryotic membranes is phosphatidylcholine (PC),
comprising~ 50% of phospholipid content. PC metabolic pathways are highly conserved …
comprising~ 50% of phospholipid content. PC metabolic pathways are highly conserved …
[HTML][HTML] Yeast and cancer cells–common principles in lipid metabolism
K Natter, SD Kohlwein - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2013 - Elsevier
One of the paradigms in cancer pathogenesis is the requirement of a cell to undergo
transformation from respiration to aerobic glycolysis–the Warburg effect–to become …
transformation from respiration to aerobic glycolysis–the Warburg effect–to become …
Phosphorylation-mediated regulation of the Nem1-Spo7/Pah1 phosphatase cascade in yeast lipid synthesis
The PAH1-encoded phosphatidate phosphatase, which catalyzes the dephosphorylation of
phosphatidate to produce diacylglycerol, controls the divergence of phosphatidate into …
phosphatidate to produce diacylglycerol, controls the divergence of phosphatidate into …
Inhibition of Plasmodium falciparum Choline Kinase by Hexadecyltrimethylammonium Bromide: a Possible Antimalarial Mechanism
Choline kinase is the first enzyme in the Kennedy pathway (CDP-choline pathway) for the
biosynthesis of the most essential phospholipid, phosphatidylcholine, in Plasmodium …
biosynthesis of the most essential phospholipid, phosphatidylcholine, in Plasmodium …
Cross-talk phosphorylations by protein kinase C and Pho85p-Pho80p protein kinase regulate Pah1p phosphatidate phosphatase abundance in Saccharomyces …
Yeast Pah1p is the phosphatidate phosphatase that catalyzes the penultimate step in
triacylglycerol synthesis and plays a role in the transcriptional regulation of phospholipid …
triacylglycerol synthesis and plays a role in the transcriptional regulation of phospholipid …
Involvement of human choline kinase alpha and beta in carcinogenesis: a different role in lipid metabolism and biological functions
D Gallego-Ortega, TG del Pulgar, F Valdés-Mora… - Advances in enzyme …, 2011 - Elsevier
Human choline kinase alpha (ChoKa) 2 and beta (ChoKb) are members of a family of
enzymes involved in the regulation of lipid metabolism. In humans this family is encoded by …
enzymes involved in the regulation of lipid metabolism. In humans this family is encoded by …
Antagonistic Interactions Between the cAMP-Dependent Protein Kinase and Tor Signaling Pathways Modulate Cell Growth in Saccharomyces cerevisiae
V Ramachandran, PK Herman - Genetics, 2011 - academic.oup.com
Eukaryotic cells integrate information from multiple sources to respond appropriately to
changes in the environment. Here, we examined the relationship between two signaling …
changes in the environment. Here, we examined the relationship between two signaling …
Flux control through protein phosphorylation in yeast
Protein phosphorylation is one of the most important mechanisms regulating metabolism as
it can directly modify metabolic enzymes by the addition of phosphate groups. Attributed to …
it can directly modify metabolic enzymes by the addition of phosphate groups. Attributed to …
Balance of human choline kinase isoforms is critical for cell cycle regulation: implications for the development of choline kinase‐targeted cancer therapy
The enzyme choline kinase (CK), which catalyzes the phosphorylation of choline to
phosphorylcholine in the presence of ATP, has an essential role in the biosynthesis of …
phosphorylcholine in the presence of ATP, has an essential role in the biosynthesis of …