Historically, systemic self-inflammatory conditions were classified as either autoinflammatory
and caused by the innate immune system or autoimmune and driven by adaptive immune …

IL-1 is a master cytokine of local and systemic inflammation. With the availability of specific
IL-1 targeting therapies, a broadening list of diseases has revealed the pathologic role of IL …

The inflammasomes control the bioactivity of pro-inflammatory cytokines of the interleukin
(IL)-1 family. The inflammasome assembled by NLRP3 has been predominantly studied in …

Regulatory B cells restrict immune and inflammatory responses across a number of contexts.
This capacity is mediated primarily through the production of IL-10. Here we demonstrate …

Cell stress is implicated in triggering bouts of systemic inflammation in patients with
autoinflammatory disorders. Blood monocytes from patients affected by NLRP3-mediated …

There is an expanding role for interleukin (IL)-1 in diseases from gout to cancer. More than
any other cytokine family, the IL-1 family is closely linked to innate inflammatory and immune …

A complex web of dynamic relationships between innate and adaptive immunity is now
evident for many autoinflammatory and autoimmune disorders, the first deriving from …

Иммуновоспалительные заболевания человека в зависимости от преобладающих
механизмов активации иммунитета разделяются на две основные категории …

Transcriptomics, the high-throughput characterization of RNAs, has been instrumental in
defining pathogenic signatures in human autoimmunity and autoinflammation. It enabled the …

Translational research approaches brought major changes to the understanding and
treatment options of autoinflammatory diseases. Patients with common complex …