Unraveling particle formation: From single droplet drying to spray drying and electrospraying

E Boel, R Koekoekx, S Dedroog, I Babkin, MR Vetrano… - Pharmaceutics, 2020 - mdpi.com
Spray drying and electrospraying are well-established drying processes that already have
proven their value in the pharmaceutical field. However, there is currently still a lack of …

Scale-up of pharmaceutical spray drying using scale-up rules: A review

S Poozesh, E Bilgili - International Journal of Pharmaceutics, 2019 - Elsevier
Spray drying is one of the widely used manufacturing processes in pharmaceutical industry.
While there are voluminous experimental studies pertaining to the impact of various process …

[HTML][HTML] Particle structure development during spray drying from a single droplet to pilot-scale perspective

NM Eijkelboom, AP van Boven, I Siemons… - Journal of Food …, 2023 - Elsevier
Crucial for achieving premium agglomerated powder products through spray drying is that
the primary particle morphology and the degree of agglomeration can be controlled …

Quality by design thinking in the development of long-acting injectable PLGA/PLA-based microspheres for peptide and protein drug delivery

C Zhang, L Yang, F Wan, H Bera, D Cun… - International journal of …, 2020 - Elsevier
Abstract Adopting the Quality by Design (QbD) approach in the drug development process
has transformed from “nice-to-do” into a crucial and required part of the development …

On the particle formation of leucine in spray drying of inhalable microparticles

M Ordoubadi, FKA Gregson, H Wang… - International journal of …, 2021 - Elsevier
The particle formation of L-leucine, a dispersibility-enhancing amino acid used in the spray
drying of inhalable pharmaceutical aerosols, was extensively studied using three …

Comparison of blueberry powder produced via foam‐mat freeze‐drying versus spray‐drying: evaluation of foam and powder properties

S Darniadi, P Ho, BS Murray - Journal of the Science of Food …, 2018 - Wiley Online Library
BACKGROUND Blueberry juice powder was developed via foam‐mat freeze‐drying (FMFD)
and spray‐drying (SD) via addition of maltodextrin (MD) and whey protein isolate (WPI) at …

PLGA-based implants for sustained delivery of peptides/proteins: Current status, challenge and perspectives

F Hu, J Qi, Y Lu, H He, W Wu - Chinese Chemical Letters, 2023 - Elsevier
Peptide and protein drugs with therapeutic effects suffer from their short half-life and low
stability, albeit their high efficiency and specificity. To overcome these demerits, long-acting …

Effect of crystallization kinetics on the properties of spray dried microparticles

A Baldelli, RM Power, REH Miles, JP Reid… - Aerosol Science and …, 2016 - Taylor & Francis
ABSTRACT A droplet chain technique was used to study the influence of the crystallization
process on the morphology of spray dried microparticles. A piezoceramic dispenser …

Producing powders containing active dry probiotics with the aid of spray drying

N Fu, S Huang, J Xiao, XD Chen - Advances in food and nutrition research, 2018 - Elsevier
Probiotics are microorganisms capable of conferring health benefits to humans and animals
when ingested. Probiotic products that prevail in food market usually contain viable bacteria …

[HTML][HTML] The role of viscosity in morphology development during single droplet drying

EM Both, I Siemons, RM Boom, MAI Schutyser - Food Hydrocolloids, 2019 - Elsevier
Particle morphology influences the final quality of a powdered product. However, the
mechanisms behind morphology formation are not completely understood yet. In this study …