Myocardial fibrosis (MF) represents the underlying pathologic condition of many cardiac
disease, leading to cardiac dysfunction and heart failure (HF). Biopsy studies have shown …

Background Pimobendan has been proven to delay the onset of congestive heart failure
(CHF) in dogs with mitral regurgitation (MR); however, molecular underlying mechanisms …

Doppler echocardiography is the corner-stone of non-invasive investigation of patients with
a clinical diagnosis of heart failure. It provides an accurate and quantitative assessment of …

Frequent premature ventricular contractions (PVCs) promoted eccentric cardiac hypertrophy
and reduced ejection fraction (EF) in a large animal model of PVC‐induced cardiomyopathy …

Echocardiography is frequently used to evaluate cardiac function in rodent models of
cardiovascular disease. Whereas methods to acquire the commonly used echocardiography …

Heart failure is a condition caused by a variety of pathophysiological factors. One important
pathological change of chronic heart failure is myocardial hypertrophy. In recent years …

Introduction: Mitral regurgitation (MR) imposes volume overload on the left ventricle (LV) and
elevates wall stress, triggering its adverse remodeling. Pronounced LV dilation, minimal wall …

The mammalian neonatal heart can regenerate for 1 week after birth, after which, the
majority of cardiomyocytes exit the cell cycle. Recent studies demonstrated that calcineurin …

Cardiomyocyte growth can occur in both physiological (exercised-induced) and pathological
(eg, volume overload and pressure overload) conditions leading to left ventricular (LV) …

Background/Objectives: In patients with chronic primary mitral regurgitation (MR),
postoperative persistent left ventricular (LV) dysfunction underlines the lack of a sensitive …