Bladder cancer—the tenth most frequent cancer worldwide—has a heterogeneous natural
history and clinical behaviour. The predominant histological subtype, urothelial bladder …

There is currently a worldwide consensus and recognition of the undoubted health benefits
of the so-called Mediterranean diet, with its intake being associated with a lower risk of …

Effective cancer therapy requires identification of signaling networks and investigating their
potential role in proliferation and invasion of cancer cells. Among molecular pathways …

Background Metformin has been reported to function as the anti-tumor inhibiting the growth
of different types of cancers, including bladder cancer. But there are few reports on the roles …

Metformin, a biguanide derivative that is widely used for treating type 2 diabetes mellitus,
has recently been shown to exert potential anticancer effects. Many retrospective data and …

Context Metformin induced AMP-activated protein kinase (AMPK) and protected neurons in
cerebral ischaemia. Objective This study examined pretreatment with metformin and …

Pre‑clinical and on‑going trials have indicated the advantage of using metformin as an
anticancer drug alone or in combination with other chemotherapeutics for the treatment of …

Background: Recent clinical trials indicated that metformin intake might play a protective role
in the incidence and oncologic outcomes of various cancers. However, its protective effect …

Breast cancer is reported as the most frequent tumor with limited treatments among the
female worldwide. Galangin, a natural active compound 3, 5, 7-trihydroxyflavone, is a type of …

Bladder cancer is a therapeutically challenging disease and wealth of knowledge has
enabled researchers to develop a clear understanding of mechanisms which underlie …