The roles of metallothioneins in carcinogenesis

M Si, J Lang - Journal of hematology & oncology, 2018 - Springer
Metallothioneins (MTs) are small cysteine-rich proteins that play important roles in metal
homeostasis and protection against heavy metal toxicity, DNA damage, and oxidative stress …

Metallothioneins in human tumors and potential roles in carcinogenesis

MG Cherian, A Jayasurya, BH Bay - Mutation Research/Fundamental and …, 2003 - Elsevier
Metallothioneins (MT) are a group of low-molecular weight, cysteine rich intracellular
proteins, which are encoded by a family of genes containing at least 10 functional isoforms …

Cancer cell states recur across tumor types and form specific interactions with the tumor microenvironment

D Barkley, R Moncada, M Pour, DA Liberman, I Dryg… - Nature …, 2022 - nature.com
Transcriptional heterogeneity among malignant cells of a tumor has been studied in
individual cancer types and shown to be organized into cancer cell states; however, it …

Cadmium, lead, and arsenic contamination in paddy soils of a mining area and their exposure effects on human HEPG2 and keratinocyte cell-lines

S Xue, L Shi, C Wu, H Wu, Y Qin, W Pan, W Hartley… - Environmental …, 2017 - Elsevier
A mining district in south China shows significant metal (loid) contamination in paddy fields.
In the soils, average Pb, Cd and As concentrations were 460.1, 11.7 and 35.1 mg kg− 1 …

Single‐nucleus RNA sequencing and spatial transcriptomics reveal the immunological microenvironment of cervical squamous cell carcinoma

Z Ou, S Lin, J Qiu, W Ding, P Ren, D Chen… - Advanced …, 2022 - Wiley Online Library
The effective treatment of advanced cervical cancer remains challenging. Herein, single‐
nucleus RNA sequencing (snRNA‐seq) and SpaTial enhanced resolution omics …

Mammalian metallothioneins: properties and functions

P Babula, M Masarik, V Adam, T Eckschlager… - Metallomics, 2012 - academic.oup.com
Metallothioneins (MT) are a family of ubiquitous proteins, whose role is still discussed in
numerous papers, but their affinity to some metal ions is undisputable. These cysteine-rich …

Exposure to pesticide residues in honey and its potential cancer risk assessment

SA Ashraf, D Mahmood, OE Abd Elmoneim… - Food and Chemical …, 2023 - Elsevier
Honey is the most recognized natural food by-product of flower nectar and the upper aero-
digestive tract of the honeybees. Significance of honey for its medicinal importance are well …

[HTML][HTML] Cadmium and breast cancer–current state and research gaps in the underlying mechanisms

K Tarhonska, M Lesicka, B Janasik, J Roszak… - Toxicology Letters, 2022 - Elsevier
Cadmium (Cd), a heavy metal with strong carcinogenic properties has been linked with
breast cancer risk. Epidemiological data on the association between Cd exposure and …

[HTML][HTML] Metallothionein: an overview

N Thirumoorthy, KTM Kumar, AS Sundar… - World journal of …, 2007 - ncbi.nlm.nih.gov
Metallothioneins (MTs) were discovered in 1957 by Margoshes and Vallee and identified as
low-molecular weight and sulphydryl rich proteins. It is not surprising that most mammalian …

Vanadium in the detection, prevention and treatment of cancer: the in vivo evidence

A Bishayee, A Waghray, MA Patel, M Chatterjee - Cancer Letters, 2010 - Elsevier
Vanadium, a dietary micronutrient, is yet to be established as an essential part of the human
diet. Over the past century, several biological effects of vanadium, such as insulin-mimetic …