Since the discovery of the first trypsinogen mutation in families with hereditary pancreatitis,
pancreatic genetics has made rapid progress. The identification of mutations in genes …

Premature activation of digestive enzymes in the pancreas has been linked to development
of pancreatitis for more than a century. Recent development of novel models to study the …

Chronic pancreatitis is a multifactorial, fibroinflammatory syndrome in which repetitive
episodes of pancreatic inflammation lead to extensive fibrotic tissue replacement, resulting …

Diese Leitlinie umfasst erstmals die akute wie auch die chronische Pankreatitis, um so
Übergänge der beiden ehemals getrennt wahrgenommenen Krankheitsbilder gemäß einem …

Objectives: Rare pathogenic variants in the SPINK1, PRSS1, CTRC, and CFTR genes have
been strongly associated with a risk of developing chronic pancreatitis (CP). However, their …

Based on the recognition of common etiological and genetic risk factors, acute and chronic
pancreatitis are increasingly regarded as a continuum of the same disease, with a significant …

Chemotherapy and radiation not only trigger cancer cell apoptosis but also damage stromal
cells in the tumour microenvironment (TME), inducing a senescence-associated secretory …

Background & Aims Acute pancreatitis (AP) is a complex disease and the leading cause of
gastrointestinal disease–related hospital admissions. Few therapeutic options exist for AP …

Pancreatitis is regarded by clinicians as one of the most complicated and clinically
challenging of all disorders affecting the abdomen. It is classified on the basis of clinical …

Objective Chronic pancreatitis is a progressive, relapsing inflammatory disorder of the
pancreas, which often develops in the background of genetic susceptibility. Recently, loss-of …